Abyssinone V-4’ Methyl Ether Isolated from Erythrina droogmansiana (Leguminosae) Inhibits Cell Growth and Mammary Glands Hyperplasia Induced in Swiss Mice by the 7,12-Dimethylbenz(a)anthracene

Table 3

Effects of Abyssinone V-4’ methyl etheron relative wet weights of various organs following 28 days of treatments.

Organs	Control	DMBA	DMBA + AVME 10
Uterus	1539.63 ± 372.67	2048.19 ± 184.88	2165.28 ± 180.21
Liver	40621.32 ± 951.37	36907.63 ± 373.71	44855.91 ± 490.77
Lungs	8426.95 ± 422.95	10602.41 ± 888.25	12583.0 ± 812.51
Spleen	4322.87 ± 201.90	2851.40 ± 380.63	3420.04 ± 609.28
Adrenals	675.79 ± 76.03	441.76 ± 69.19	571.00 ± 90.5
Kidneys	10004.61 ± 801.91	11405.62 ± 714.75	11153.19 ± 643.13
Femur	2572.63 ± 553.63	2428.19 ± 81.83	2669.94 ± 124.11
Brain	2580.84 ± 111.1	3052.21 ± 171.22	2535.22 ± 127.81
Ovaries	408.40 ± 70.44	321.28 ± 71.22	546.60 ± 67.50

Control = normal mice treated with distilled water; DMBA = negative control treated with distilled water; DMBA + AVME 10 = animals treated with the Abyssinone V-4’ methyl etherat the dose of 10 mg/kg. All groups except the normal group (control) received an intragastric dose of DMBA at the dose of 100 mg/kg. Data are represented as mean ± SD (n = 5). and as compared to normal group.