(i) Increases the efficacy of herceptin by reducing FoxM1, Akt, and NF-κB p65 level (ii) Increases the chemosensitivity of tamoxifen and alter the estrogen metabolism in randomized, placebo-controlled trial (iii) Sensitizes MDR human breast carcinoma to γ-irradiation
(i) Increases p53 level (ii) Increases Bax expression (iii) Downregulates NF-kappaB, cyclin D, and MMP-1 transcription in MDA-MB-231 and BT-483 cell line
(i) Enhances the efficacy of paclitaxel by deactivating NF-κB and MMP-9 expressions in MDA-MB-231 cell (ii) Inhibits the efflux function of P-gp, MXR, and MRP1 in MCF-7 and MCF-7MDR cell line
(i) Decreases 5-methylcytosine, DNA methyltransferase (DNMT) activity, DNMT1, DNMT3a, and DNMT3b (ii) Decreases histone deacetylase activity (iii) Increases levels of acetylated lysine 9 and 14 on histone H3 (H3-Lys 9 and 14) and acetylated lysine 5, 12, and 16 on histone H4 (iv) Decreases the levels of methylated H3-Lys 9. (v) Increases the expression of p16INK4a and Cip1/p21. (vi) Induces the expression of epigenetically repressed TIMP-3 gene
(i) Decreases aryl hydrocarbon- (AhR-) regulated genes (ii) Blocks ERβ-specific inhibitor PHTPP (iii) Decreases the expression of Bcl-2 but increases Bax (iv) Increases release of cytochrome c (v) Increases the expression of Apaf-1 (vi) Activates of caspase-3 and poly(ADP-ribose) polymerase (vii) Alters the EGFR activity (viii) Increases the expression of p21 and p27, caspase-3, caspase-8, and caspase-9 and TP53
(i) Inhibits COX-2 expression (ii) Regulates PGE2 (iii) Inhibits sPLA2, NF-κB, and ERK mediated phosphorylation of p65 in breast cancer cell (iv) Activates both ERα and ERβ
(i) Upregulation of Bax and p21WAF1 protein in MDA-MB-231 cell lines (ii) Downregulation of caspase-3 (iii) Regulates calpain-caspase-7 and 1-p38 mitogen-activated protein kinase activation cascades (iv) Inactivates the IGF-1R-PI3K/Akt pathway and reducing the Bcl-2/Bax (v) Enhances G2/M arrest by activating the ATM/Chk2/Cdc25C/Cdc2 checkpoint pathway
(i) Blocks the phosphorylation of Akt downstream pathway (ii) Upregulates the proapoptotic Bax without affecting antiapoptotic Bcl-xL (iii) Suppresses cyclin D1 and upregulates p21 (iv) Sustains the activation of the ERK1/2 (v) Increases the expression of p53 and Bax
(i) Increases the expression cyclin B1 (ii) Activates the poly(ADP-ribose) polymerase 1 and caspase family proteins (iii) Inhibits tubulin polymerization (iv) Downregulates the nuclear factor kappa B signaling pathway (v) Decreases the expressions of Bcl-2 and phosphorylated Akt serine/threonine kinase
(i) Increases chemosensitivity of paclitaxel in breast cancer cells (ii) Enhances the sensitivity of tamoxifen by epigenetic reactivation of ERα in ERα-negative breast cancer
(i) Decreases the expressions of SOX9 and ALDH1 in vivo (ii) Decreases ALDH+ and downregulates the Wnt/β-catenin self-renewal pathways in NOD/SCID xenograft model at a dose of 50 mg/kg for 2 weeks
(i) Activates ER ubiquitination (ii) Inhibits pS2 and c-myc, estrogen responsive gene promoters (iii) Induces DNA damage by triggering the Nrf2 pathway
(i) Decreases the expressions of steroid sulfatase genes (ii) Activates caspase-3 (iii) Suppresses NF-κB pathway, Bcl-2, and Bax (iv) Downregulates p65 and inhibition of IκB-α phosphorylation
(i) Increases the chemosensitivity of taxol in ER negative human breast cells (ii) Induces cell cycle arrest at the G2/M phase and inhibits the activation of ERK, Akt, and p70S6 kinases (iii) Decreases tamoxifen resistance by inducing uc.57 and downregulates BCL11A
(i) Inhibits DNMT 3b expression and decreases RASSF-1α methylation (ii) Activates SIRT1 and acetyl transferase p300 (iii) Decreases the expressions of DNMT1, DNMT3a, and DNMT3b, HDAC1, and methyl CpG binding protein 2 (MeCP2) in MCF-7 cell line
(i) Consumption of 1 g resveratrol per day had complimentary effects on estrogen metabolism as well as sex steroid hormone binding globulin in postmenopausal women having high body mass index
(i) Stimulates p53-dependent pathway at a low dose in MCF-7 cells (ii) Suppresses ER- dependent PI3K pathway (iii) Src tyrosine kinase and signal transducer and activator of transcription 3 (STAT-3) phosphorylation pathways (iv) Reduces Akt phosphorylation and activates of procaspase-9 (v) Activates mitochondrial protein (Smac/DIABLO), caspase-9, and caspase-3
(i) Reduces the COX-2 expression, AP-1 activation, and antagonized the ERK1/2 activation (ii) Suppresses interleukin-8 (IL-8) in the pathway of the NF-κB
(i) Restores the chemosensitivity in HER2-negative and triple-negative breast cancer cell lines (ii) Reduces c-Met kinase activity in TNBC cell line and also significantly reduces the growth of TNBC MDA-MB-231/GFP orthotopic xenograft in nude mouse model at a dose of 30 mg/kg