Treatment of Urolithiasis with Medicinal Plant Salvia miltiorrhiza: A Nationwide Cohort Study
Table 2
Incidence rates, hazard ratio, and confidence intervals of calculus surgical treatment and any bleeding disorder for calculus patients using and not using Danshen in the stratification of sex and age.
Variables
Using Danshen in calculus patients
Crude HR
Adjusted HR
No
Yes
()
()
Event
Person-years
IR
Event
Person-years
IR
(95% CI)
(95% CI)
Outcome: calculus surgical treatment
Total
1370
43605
31.42
574
53589
10.71
0.36 (0.33–0.4)
0.34 (0.31–0.38)
Sex
Female
615
25057
24.54
208
30354
6.85
0.3 (0.26–0.35)
0.29 (0.24–0.34)
Male
755
18548
40.70
366
23235
15.75
0.41 (0.36–0.47)
0.39 (0.34–0.44)
Age group, years
18–39
449
16784
26.75
215
19782
10.87
0.43 (0.36–0.5)
0.4 (0.34–0.47)
40–64
799
22739
35.14
320
28151
11.37
0.35 (0.3–0.39)
0.33 (0.29–0.38)
≥65
122
4082
29.89
39
5656
6.90
0.26 (0.18–0.37)
0.25 (0.17–0.35)
Outcome: any bleeding disorders
Total
1138
44166
25.77
917
53678
17.08
0.66 (0.61–0.72)
0.61 (0.56–0.67)
Sex
Female
572
25341
22.57
463
30379
15.24
0.68 (0.6–0.77)
0.63 (0.56–0.71)
Male
566
18824
30.07
454
23299
19.49
0.64 (0.57–0.73)
0.59 (0.52–0.67)
Age group, years
18–39
202
16862
11.98
162
19786
8.19
0.68 (0.56–0.84)
0.65 (0.53–0.8)
40–64
629
23102
27.23
516
28238
18.27
0.67 (0.59–0.75)
0.63 (0.56–0.71)
≥65
307
4202
73.07
239
5653
42.28
0.58 (0.49–0.69)
0.55 (0.46–0.65)
IR, incidence rates per 1,000 person-years; HR, hazard ratio; CI, confidence interval. Adjusted HR represented adjusted hazard ratio: mutually adjusted for Danshen drug used, sex, age, diabetes mellitus, urinary tract infection, hypertension, chronic kidney disease, and gout in Cox proportional hazard regression. .
