JYYS Granule Mitigates Renal Injury in Clinic and in Spontaneously Hypertensive Rats by Inhibiting NF-B Signaling-Mediated Microinflammation

Figure 2

JYYS granule mitigates histological changes of glomerular injury in SHR. (a) HE staining under light microscopy (×200): WKY group, SHR group, Benazepril group (SHR), JYYS (H), JYYS (M), and JYYS (L). In the SHR group, glomeruli showed hyperemia, focal tubular epithelial cells were swollen with inflammatory cells infiltration, and partial arterioles showed wall thickening. These abnormal changes were attenuated by Benazepril as well as JYYS granule. No abnormality was found in the WKY group. (b) HE staining under electron microscopy (×4000): WKY group, SHR group, Benazepril group (SHR), JYYS (H), JYYS (M), and JYYS (L). In the SHR group, there was basal membrane thickening, and focal foot processes were fused and disarranged. No abnormality was found in the WKY group. The dysfunction was mitigated by Benazepril and JYYS granule.

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