Simultaneous Determination of Columbianadin and Its Metabolite Columbianetin in Rat Plasma by LC-MS/MS: Application to Pharmacokinetics of Columbianadin after Oral Administration

Table 4

Main pharmacokinetic parameters of columbianadin and columbianetin in rats after oral administration (n =10, mean ± SD).

	Administration of columbianadin		Administration of APR extract
Parameters	Columbianadin	Columbianetin	Columbianadin	Columbianetin
t1/2(h)	5.15 ± 4.58	3.44 ± 1.95	0.92 ± 0.36	4.52 ± 3.19
(h)	3.03 ± 1.87	3.30 ± 1.89	0.55 ± 0.33	4.60 ± 1.65
(ng/mL)	13.33 ± 25.37	3.12 ± 0.93	1.82 ± 0.64	631.40 ± 427.10
(ng/mL h)	28.80 ± 41.46	18.51 ± 13.26	1.05 ± 1.02	3346 ± 2550
(ng/mL h)	47.95 ± 66.80	23.88 ± 15.53	3.23 ± 1.46	3490 ± 2489
(h)	6.38 ± 4.96	5.76 ± 1.65	0.78 ± 0.20	4.79 ± 0.76
(h)	6.37 ± 1.46	8.72 ± 2.14	1.99 ± 0.59	5.67 ± 1.11