Research Article
Subchronic and Genetic Safety Assessment of a New Medicinal Dendrobium Species: Dendrobium Taiseed Tosnobile in Rats
Table 4
Absolute organ weight of SD male and female rats fed with 800, 1600, and 2400 mg/kg DTTE for 90 days.
| | Item | Control | 800 mg | 1600 mg | 2400 mg |
| Brain (g)
(g/100 g b.w.) | | | | | | M | 2.19 ± 0.11 | 2.21 ± 0.09 | 2.14 ± 0.05 | 2.16 ± 0.08 | | (0.42 ± 0.04) | (0.42 ± 0.03) | (0.40 ± 0.03) | (0.42 ± 0.04) | | F | 2.03 ± 0.02 | 1.99 ± 0.02 | 2.07 ± 0.01 | 2.01 ± 0.02 | | (0.73 ± 0.04) | (0.71 ± 0.06) | (0.74 ± 0.05) | (0.72 ± 0.04) | Pituitary (mg)
(mg/100 g b.w.) | | | | | | M | 13.3 ± 6.8 | 10.3 ± 1.5 | 10.6 ± 1.5 | 12.4 ± 5.1 | | (2.5 ± 1.4) | (2.0 ± 0.4) | (2.0 ± 0.4) | (2.4 ± 0.9) | | F | 15.8 ± 2.3 | 17.4 ± 6.6 | 14.6 ± 2.8 | 13.2 ± 3.0 | | (5.5 ± 0.8) | (6.2 ± 2.4) | (5.3 ± 1.3) | (4.7 ± 1.1) | Heart (g)
(g/100 g b.w.) | | | | | | M | 1.52 ± 0.13 | 1.52 ± 0.13 | 1.49 ± 0.11 | 1.52 ± 0.13 | | (0.29 ± 0.03) | (0.29 ± 0.03) | (0.28 ± 0.02) | (0.29 ± 0.03) | | F | 0.93 ± 0.10 | 0.94 ± 0.09 | 0.94 ± 0.06 | 0.95 ± 0.10 | | (0.33 ± 0.03) | (0.34 ± 0.04) | (0.34 ± 0.04) | (0.34 ± 0.03) | Liver (g)
(g/100 g b.w.) | | | | | | M | 12.7 ± 2.1 | 12.0 ± 1.6 | 11.8 ± 1.7 | 12.3 ± 1.8 | | (2.4 ± 0.4) | (2.3 ± 0.3) | (2.2 ± 0.3) | (2.4 ± 0.4) | | F | 6.8 ± 0.5 | 6.7 ± 0.6 | 6.7 ± 0.5 | 7.0 ± 0.7 | | (2.4 ± 0.2) | (2.4 ± 0.3) | (2.4 ± 0.3) | (2.5 ± 0.2) | Spleen (g)
(g/100 g b.w.) | | | | | | M | 0.82 ± 0.09 | 0.79 ± 0.09 | 0.80 ± 0.09 | 0.80 ± 0.06 | | (0.16 ± 0.02) | (0.15 ± 0.02) | (0.15 ± 0.02) | (0.16 ± 0.01) | | F | 0.54 ± 0.09 | 0.54 ± 0.06 | 0.54 ± 0.07 | 0.50 ± 0.03 | | (0.19 ± 0.03) | (0.19 ± 0.02) | (0.20 ± 0.03) | (0.18 ± 0.01) | | L kidneys (g) (g/100 g b.w.) | | | | | | M | 1.63 ± 0.12 | 1.52 ± 0.13 | 1.51 ± 0.11 | 1.55 ± 0.12 | | (0.31 ± 0.03) | (0.29 ± 0.03) | (0.28 ± 0.02) | (0.32 ± 0.09) | | F | 0.83 ± 0.09 | 0.84 ± 0.08 | 0.85 ± 0.07 | 0.82 ± 0.07 | | (0.30 ± 0.04) | (0.30 ± 0.03) | (0.30 ± 0.04) | (0.29 ± 0.02) | R kidneys (g)
(g/100 g b.w.) | | | | | | M | 1.66 ± 0.11 | 1.54 ± 0.12 | 1.54 ± 0.10 | 1.53 ± 0.13 | | (0.31 ± 0.03) | (0.29 ± 0.02) | (0.29 ± 0.02) | (0.27 ± 0.06) | | F | 0.86 ± 0.09 | 0.87 ± 0.09 | 0.85 ± 0.06 | 0.84 ± 0.07 | | (0.31 ± 0.04) | (0.31 ± 0.04) | (0.31 ± 0.04) | (0.30 ± 0.02) | L adrenal (mg)
(mg/100 g b.w.) | | | | | | M | 25.0 ± 1.4 | 29.6 ± 1.5 | 29.7 ± 1.7 | 27.3 ± 1.4 | | (4.8 ± 1.0) | (5.6 ± 1.0) | (5.6 ± 0.8) | (5.3 ± 1.0) | | F | 31.3 ± 6.1 | 32.6 ± 5.5 | 30.0 ± 4.5 | 32.6 ± 6.1 | | (11.2 ± 2.3) | (11.7 ± 1.9) | (10.7 ± 2.0) | (11.7 ± 2.5) | R adrenal (mg)
(mg/100 g b.w.) | | | | | | M | 25.9 ± 3.9 | 28.4 ± 4.7 | 27.6 ± 4.2 | 24.4 ± 4.0 | | (4.9 ± 0.8) | (5.4 ± 0.9) | (5.2 ± 0.7) | (4.7 ± 0.8) | | F | 30.0 ± 6.2 | 31.4 ± 6.6 | 28.8 ± 3.8 | 31.1 ± 6.8 | | (10.6 ± 2.0) | (11.3 ± 2.7) | (10.3 ± 1.9) | (11.1 ± 2.6) | L testis (g)
(g/100 g b.w.) | | | | | | M | 1.74 ± 0.13 | 1.72 ± 0.14 | 1.76 ± 0.12 | 1.71 ± 0.23 | | (0.33 ± 0.03) | (0.33 ± 0.03) | (0.33 ± 0.04) | (0.33 ± 0.05) | R testis (g)
(g/100 g b.w.) | | | | | | M | 1.72 ± 0.13 | 1.73 ± 0.13 | 1.76 ± 0.15 | 1.70 ± 0.24 | | (0.33 ± 0.03) | (0.33 ± 0.03) | (0.33 ± 0.04) | (0.33 ± 0.06) | L ovaries (mg)
(mg/100 g b.w.) | | | | | | F | 53.3 ± 10.1 | 55.6 ± 8.0 | 56.4 ± 7.0 | 47.3 ± 8.5 | | (19.2 ± 4.4) | (19.9 ± 3.2) | (20.3 ± 3.9) | (16.9 ± 3.4) | R ovaries (mg)
(mg/100 g b.w.) | | | | | | F | 58.1 ± 7.8 | 57.4 ±10.2 | 59.5 ± 8.4 | 50.2 ± 7.1 | | (20.8 ± 3.1) | (20.6 ± 4.0) | (21.3 ± 4.1) | (17.9 ± 2.6) |
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All values are means ± SD ( ). ( ): relative weight; b.w.: body weight; M: male; F: female; L: left; and R: right. |
