Subchronic and Genetic Safety Assessment of a New Medicinal Dendrobium Species: Dendrobium Taiseed Tosnobile in Rats
Table 5
Histopathological examination of SD male and female rats fed with 800, 1600, and 2400 mg/kg DTTE for 90 days.
Organ
Lesions
Group
Male
Female
H2O
DTTE 2.4 g/kg
H2O
DTTE 2.4 g/kg
Adrenal
-
-
-
-
Aorta
-
-
-
-
Brain
-
-
-
-
Brain stem
-
-
-
-
Bone
-
-
-
-
Bone marrow
-
-
-
-
Esophagus
-
-
-
-
Eye
-
-
-
-
Heart
Infiltration, mononuclear cell, focal, minimal to slight2
2/101
1/10
-
-
Intestine
-
-
-
-
Kidney
Hydronephrosis, pelvis, focal, slight to moderate
2/10
-
-
-
Infiltration, mononuclear cell, focal, slight
1/10
-
-
-
Regeneration, tubule, focal, slight
1/10
-
-
-
Liver
-
-
-
-
Lung
-
-
-
-
Lymph node
-
-
-
-
Ovary
N
N
-
-
Oviduct
N
N
-
-
Pancreas
-
-
-
-
Parathyroid gland
-
-
-
-
Prostate
Infiltration, mononuclear cell, focal, slight
2/10
2/10
N
N
Sciatic nerve
-
-
-
-
Seminal vesicle
-
-
-
-
Skeletal muscle
-
-
-
-
Spinal cord
-
-
-
-
Stomach
-
-
-
-
Epidermoid cyst, focal, moderate
-
-
-
1/10
Spleen
-
-
-
-
Testes
-
-
N
N
Thymus
-
-
-
-
Thyroid gland
-
-
-
-
Trachea
-
-
-
-
Urinary bladder
-
-
-
-
Uterus
N
N
-
-
Vagina
N
N
-
-
: number of affected rats/number of rats were examined. of lesions was graded from one to five depending on severity: 1 = minimal (<1%); 2 = slight (1–25%); 3 = moderate (26–50%); 4 = moderate/severe (51–75%); and 5 = severe/high (76–100%).
