Evidence-Based Complementary and Alternative Medicine

Research Article

Cytotoxic Activity of Extracts from Plants of Central Argentina on Sensitive and Multidrug-Resistant Leukemia Cells: Isolation of an Active Principle from Gaillardia megapotamica

Table 1

Antiproliferative activity of extracts obtained from native and naturalized plants of central Argentina.


Species	Cytotoxicity (%)
Species	CCRF-CEM	CEM/ADR5000	K562	Lucena

Acacia aroma Gillies ex Hook. & Arn	21 ± 6	63 ± 6	0	0
Acacia atramentaria Benth.	23 ± 2	20 ± 3	0	0
Acalypha communis Müll. Arg.	12 ± 1	16 ± 2	14 ± 7	18 ± 6
Acanthostyles buniifolius (Hook. & Arn.) R. M. King & H. Rob.)	100	90 ± 5	52 ± 3	41 ± 4
Achyrocline satureioides (Lam.) DC.	74 ± 1	45 ± 21	0	8 ± 2
Achyrocline tomentosa Rusby	100	78 ± 5	18 ± 8	42 ± 6
Aldama tucumanensis (Hook. & Arn.) E. E. Schill. & Panero	100	95 ± 1	74 ± 5	70 ± 2
Aloysia citriodora Palau	7 ± 2	9 ± 2	0	0
Aloysia gratissima (Gillies & Hook.) Tronc.	67 ± 4	31 ± 5	3 ± 1	0
Ambrosia elatior L.	97 ± 0	95 ± 0	81 ± 0	72 ± 3
Amphilophium carolinae (Lindl.) L. G. Lohmann	0	10 ± 11	14 ± 8	5 ± 5
Anemia tomentosa (Savigny) Sw.	1 ± 2	14 ± 6	0	15 ± 2
Araujia brachystephana (Griseb.) Fontella & Goyder	0	25 ± 6	15 ± 1	6 ± 4
Argemone subfusiformis G. B. Ownbey	0	18 ± 1	2 ± 4	7 ± 4
Aristolochia argentina Griseb.	68 ± 0	100	69 ± 1	57 ± 11
Artemisia annua L.	87 ± 2	74 ± 1	40 ± 2	48 ± 3
Artemisia verlotorum Lamotte	88 ± 3	76 ± 3	16 ± 10	58 ± 3
Astragalus distinens Macloskie	0	29 ± 3	1 ± 1	12 ± 0
Baccharis artemisioides Hook. & Arn.	93 ± 3	100	79 ± 0	78 ± 3
Baccharis coridifolia DC.	100	94 ± 1	77 ± 0	75 ± 1
Baccharis flabellata Hook. & Arn.	100	58 ± 10	27 ± 1	10 ± 4
Baccharis linearifolia (Lam.) Pers.	83 ± 10	53 ± 11	0	21 ± 9
Baccharis salicifolia (Ruiz et Pav.) Pers.	26 ± 2	26 ± 6	8 ± 9	0
Bidens pilosa L.	5 ± 7	0	23 ± 6	0
Cantinoa mutabilis (Rich.) Harley & J. F. B. Pastore	85 ± 6	99 ± 9	21 ± 8	23 ± 2
Capparis amisquea Kuntze	0	9 ± 2	18 ± 4	6 ± 1
Chromolaena hookeriana (Griseb.) R. M. King & H. Rob.	14 ± 13	10 ± 10	0	0
Condalia microphylla Cav.	19 ± 3	0	0	0
Cortaderia speciosa (Nees & Meyen) Stapf	11 ± 12	3 ± 3	0	6 ± 1
Cotoneaster glaucophyllus Franch.	0	0	19 ± 1	10 ± 3
Croton lachnostachyus Baill.	16 ± 8	39 ± 3	36 ± 3	40 ± 4
Cynoglossum amabile Stapf & J. R. Drumm.	0	22 ± 2	16 ± 2	9 ± 1
Dalea elegans Hook. & Arn.	47 ± 8	20 ± 3	3 ± 5	20 ± 6
Dimerostemma aspilioides (Griseb.) M. D. Moraes	96 ± 0	97 ± 1	90 ± 1	85 ± 1
Dipsacus fullonum L.	0	7 ± 2	18 ± 2	14 ± 2
Dolichandra cynanchoides Cham.	0	11 ± 1	0	10 ± 8
Dolichandra unguis-cati (L.) L. G. Lohmann	8 ± 9	16 ± 4	7 ± 4	5 ± 4
Dysphania ambrosioides (L.) Mosyakin & Clemants	12 ± 12	14 ± 11	0	0
Elaphoglosum lorentzii (Hieron.) H. Christ	40 ± 10	8 ± 3	0	0
Eryngium horridum Malme	0	18 ± 3	10 ± 2	0
Flourensia campestris Griseb.	83 ± 3	71 ± 4	18 ± 6	13 ± 5
Flourensia oolepis S. F. Blake	100	80 ± 3	15 ± 2	8 ± 5
Gaillardia megapotamica (Spreng.) Baker	100	100	80 ± 2	78 ± 3
Gomphrena pulchella Mart.	0	0	0	0
Grindelia pulchella Dunal	77 ± 12	91 ± 4	72 ± 2	82 ± 1
Jarava ichu Ruiz et Pav.	39 ± 2	11 ± 11	3 ± 3	0
Jodina rhombifolia (Hook. & Arn.) Reissek	33 ± 2	30 ± 6	8 ± 3	17 ± 1
Kageneckia lanceolata Ruiz & Pav.	68 ± 11	33 ± 2	6 ± 3	16 ± 3
Lantana grisebachii Seckt	96 ± 18	52 ± 12	27 ± 10	68 ± 1
Lepechinia floribunda (Benth.) Epling	100	84 ± 4	1 ± 5	1 ± 1
Lepechinia meyenii (Walp.) Epling	95 ± 0	92 ± 2	38 ± 13	31 ± 30
Lessingianthus mollissimus (Hook. & Arn.) H. Rob.	6 ± 2	25 ± 2	4 ± 5	0
Ligaria cuneifolia (Ruiz & Pav.) Tiegh.	15 ± 4	38 ± 2	13 ± 2	0
Lippia turbinata Griseb.	0	27 ± 18	15 ± 3	5 ± 7
Lithrea molleoides (Vell.) Engl.	100	52 ± 14	0	0
Lorentzianthus viscidus (Hook. & Arn.) R. M. King & H. Rob.	67 ± 15	18 ± 7	0	0
Mandevilla pentlandiana (A. DC.) Woodson	100	100	71 ± 4	60 ± 5
Marrubium vulgare L.	29 ± 9	40 ± 10	16 ± 7	11 ± 0
Melia azedarach L.	84 ± 1	11 ± 2	38 ± 12	0
Melinis repens (Willd.) Zizka	9 ± 7	14 ± 3	0	2 ± 2
Melissa officinalis L.	0	19 ± 29	0	0
Microliabum candidum (Griseb.) H. Rob.	100	100	72 ± 12	63 ± 14
Minthostachys verticillata (Griseb.) Epling	16 ± 8	55 ± 2	12 ± 11	6 ± 2
Monnina dictyocarpa Griseb.	30 ± 21	46 ± 14	8 ± 10	0
Ophryosporus charua (Griseb.) Hieron.	47 ± 14	33 ± 3	23 ± 4	36 ± 3
Pascalia glauca Ortega	27 ± 15	35 ± 3	12 ± 1	23 ± 1
Pavonia aurigloba Krapov. & Cristóbal	5 ± 3	15 ± 3	5 ± 1	0
Podranea ricasoliana (Tanfani) Sprague	40 ± 10	6 ± 6	0	26 ± 3
Porlieria microphylla (Baill.) Descole, O’Donell & Lourteig	6 ± 8	0	6 ± 8	0
Prosopis alba Griseb.	0	0	0	0
Prosopis sp.	4 ± 10	0	0	0
Pterocaulon alopecuroides (Lam.) DC	87 ± 3	87 ± 2	0	4 ± 2
Pyrostegia venusta (Ker Gawl.) Miers	10 ± 3	11 ± 1	21 ± 1	0
Ruprechtia apetala Wedd.	22 ± 7	15 ± 15	14 ± 7	1 ± 4
Salvia cuspidata Ruiz & Pav.	100	90 ± 8	14 ± 4	64 ± 0
Schizachyrium condensatum (Kunth) Nees	33 ± 3	34 ± 3	0	0
Senecio madagascariensis Poir.	14 ± 14	23 ± 4	22 ± 2	3 ± 6
Senecio viravira Hieron.	44 ± 26	47 ± 2	6 ± 3	0
Senna aphylla (Cav.) H. S. Irwin et Barneby	1 ± 2	22 ± 1	7 ± 3	10 ± 3
Sida rhombifolia L.	21 ± 5	1 ± 1	39 ± 4	0
Solanum argentinum Bitter & Lillo	53 ± 15	0	14 ± 14	17 ± 1
Solanum palinacanthum Dunal	76 ± 13	12 ± 1	64 ± 3	0
Solanum sisymbriifolium Lam.	81 ± 16	0	48 ± 1	0
Sphaeralcea cordobensis Krapov.	34 ± 11	1 ± 1	0	0
Sphaeralcea cordobensis sp. mutant Krapov.	21 ± 12	4 ± 4	7 ± 2	0
Tagetes minuta L.	26 ± 4	0	0	0
Thalictrum decipiens Boivin	13 ± 8	3 ± 3	0	9 ± 4
Thelesperma megapotamicum (Spreng.) Kuntze	37 ± 9	58 ± 12	0	5 ± 2
Trichocline reptans (Wedd.) Hieron.	10 ± 3	0	0	3 ± 0
Vernonanthura nudiflora (Less.) H. Rob.	100	96 ± 1	89 ± 4	78 ± 1
Wedelia buphtalmiflora Lorentz	5 ± 5	7 ± 5	2 ± 2	24 ± 2
Zanthoxylum coco Hook. f. & Arn.	11 ± 4	11 ± 9	87 ± 1	0

Extracts were tested at 50 μg/mL. Values are expressed as mean ± SE.