Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects

Table 3

Possible structure–activity relationship of polyynes from O. horridus against cancer.

Polyyne	Structure characteristics			Cancer cell lines	Activit	References
	Carbon chain	Hydroxyl group	Double bond
1	18	3	2	HCT-116, HT-29, SW-480, A549, MCF-7, MDA-MB-231, HepG2	Best	[22, 48, 49, 59]
2	18	3	1	HCT-116, HT-29, SW-480, A549, MCF-7, MDA-MB-231, HepG2	Better	[48, 59]
3	18	2	2	HCT-116, HT-29, SW-480, A549, MCF-7, MDA-MB-231, HepG2	Good	[47, 48, 59]
4	18	2	1	HCT-116, HT-29, SW-480, A549, MCF-7, MDA-MB-231, HepG2	Good	[47, 48, 59]
5	17	2	2	HCT-116, HT-29, SW-480, A549, MCF-7, MDA-MB-231, HepG2, DU145	Best	[23, 47, 48, 59]
6	17	2	1	HCT-116, HT-29, SW-480, A549, MCF-7, MDA-MB-231, HepG2	Better	[47, 48, 59]
7	17	1	2	Not available	Not available	[95–97]

1, oplopantriol A; 2, oplopantriol B; 3, (11S,16S,9Z)-9,17-octadecadiene-12,14-diyne-1,11,16-triol,1-acetate; 4, oplopandiol acetate; 5, falcarindiol; 6, oplopandiol; 7, falcarinol. Stereoselectivity also affects the activities discussed in the text.