Research Article

Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats

Figure 3

EZP improved the estrogen deficiency mediated bone metabolism disorder in the ovariectomized rat model. Results of ELISA assay show the serum concentration of E2 (a), SHBG (b), RANKL (c), OPG (d), OPG/RANKL (e), and BALP (f). EZP downregulated serum concentration of RANKL and upregulated serum concentration of OPG, OPG/RANKL, and BALP. means P<0.05; means P<0.01.
(a)
(b)
(c)
(d)
(e)
(f)