In Vivo Antimalarial Activity of the 80 Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei

Table 5

Body weight and rectal temperature of malaria infected mice before and after treatment with 80% methanolic extract of root barks of Gardenia ternifolia in Rane’s test.

Group	Weight (gram)			Temperature (^0c)
Dose/kg	D3	D7	% Change	D3	D7	% Change
CON	25.64±1.20	22.19±1.15	-13.54	36.40±0.25	33.10±0.26	-9.05
GT200	24.95±1.14	23.19±0.95	-6.9	35.90±0.22	34.45±0.20	-4.0
GT400	25.56±1.07	24.82±1.22	-3.0	35.87±0.24	35.10±0.35	-2.1
GT600	26.76±0.82	26.72±0.69	-0.0	36.00±0.23	35.75±0.25	-0.6
CQ25	25.79±1.04	28.85±1.22	11.8	36.07±0.25	36.85±0.17	2.1

Data are expressed as mean ± SEM (n=6); a, compared to CON; b, compared to CQ 25 mg/kg; c, compared to 200 mg/kg; d, compared to 400 mg/kg; e, compared to 600 mg/kg; ¹p< 0.05; ²p<0.01, ³p<0.001; CON, negative control; CQ, chloroquine (positive control); GT, Crude extract; D₃ = pre-Rx value on day three, D₇ = post-Rx value on day seven; numbers (25,200,400,600) refer to dose in mg/kg.