Serum Metabolomics Study Based on LC-MS and Antihypertensive Effect of Uncaria on Spontaneously Hypertensive Rats
Table 1
Potential biomarkers in samples and corresponding metabolic pathways.
Number
RT
Mass
Biomarker identification
KEGG
Change trend
Pathway
(1)
15.64
329.3297
Dihydroceramide
C12126
↑
↓
Sphingolipid metabolism
(2)
28.35
563.441
Ceramide
C00195
↑
↓
Sphingolipid metabolism
(3)
29.94
701.2065
PC(16:1(9Z)/14:1(9Z))
C00416
↓
↑
Glycerophospholipid metabolism
(4)
18.39
569.3487
LysoPC (22:5)
C04230
↑
↓
Glycerophospholipid metabolism
(5)
26.68
296.2828
Thromboxane A2
C02198
↑
↓
Arachidonic acid metabolism
(6)
26.68
255.2564
Nicotinamide riboside
C03150
↓
↑
Nicotinate and nicotinamide metabolism
(7)
0.68
220.1793
5-HTP
C00643
↑
↓
Tryptophan metabolism
Note. Trends of model group compared with normal group of metabolites. compared to normal group. Trends of Uncaria group compared with model group of metabolites. compared to model group. ↑: upregulated. ↓: downregulated.
