Research Article
Discovery of a Novel ERp57 Inhibitor as Antiplatelet Agent from Danshen (Salvia miltiorrhiza)
Figure 1
Inhibitory effect of DSE on platelet aggregation in vitro. Platelets were pretreated for 5 min with various concentrations of DSE (15, 50, 150, 450, and 1350 μg/mL), aspirin (18 μg/mL), clopidogrel bisulfate (42 μg/mL), or vehicle, followed by simulation with 0.24 mM AA (a, b), 9 μM ADP (c, d), or 10 μg/mL collagen (e, f). The platelet maximum aggregation rate of revulsant treatment group was normalized to 100%. < 0.05 compared with revulsant treatment group. Data are expressed as mean ± SD, ≥ 3/group. CB: clopidogrel bisulfate.
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