Research Article

Study of Pharmacodynamic and Pharmacokinetic Interaction of Bojungikki-Tang with Aspirin in Healthy Subjects and Ischemic Stroke Patients

Table 4

Change in pharmacokinetic and pharmacodynamic profiles and blood tests among ischemic stroke patients (phase III study).

Aspirin + placeboAspirin + BJIKT
BaselineNet change from baselineBaselineNet change from baseline

PK
 ASANS
 SANS
PD
 TxB2 (pg/ml)NS
 PLT agg (%)NS
Blood chemistry
 FBG (mg/dl)NS
 T-chol (mg/dl)NS
 TG (mg/dl)NS
 CaNS
 PNS
 Uric acidNS
Blood count
 WBCNS
 RBCNS
 HgbNS
 HctNS
 PlateletNS

BJIKT: Bojungikki-tang, ASA: acetyl salicylic acid, SA: salicylic acid, TxB2: thromboxane B2, PLT agg: platelet aggregation, FBS: fasting blood glucose, T-chol: total cholesterol, TG: triglyceride, Ca: calcium, P: phosphorus, WBC: white blood cell, RBC: red blood cell, Hgb: hemoglobin, and Hct: hematocrit.