Efficacy of Suxiao Jiuxin Pill on Coronary Heart Disease: A Meta-Analysis of Randomized Controlled Trials
Table 1
Characteristics of selected clinical trials included in the meta-analysis.
Author name
Year
Sample size
Study design
Age
Age
Country
Comparators
Dosage/frequency/cycle
Outcomes
Follow-up period
(treatment)
(control)
Suxiao jiuxin pills
Comparators
He
1995
48
RCT
42–60
40–57
China
Salvia
4# tid
3# tid
Hemorheology
4 weeks
Song
1995
149
RCT
China
Salvia
5# tid
3# tid
ECG, blood pressure, and heart rate
4 weeks
Wang
1996
60
RCT
NR
NR
China
Shexiang Baoxin pills
5# tid
3# tid
ECG and symptom
2 weeks
Ke
1996
72
RCT
45–79
46–78
China
Nitroglycerin
6# tid
0.5 mg Q8 h
ECG and symptom
4 weeks
Gao et al.
1996
147
RCT
36–85
35–84
China
Nitroglycerin
10#
0.5 mg
ECG and symptom
Immediately
Yun
1996
318
RCT
44–76
44–75
China
Isosorbide dinitrate
6–10# Q4–6 h
10# tid
ECG and symptom
2 weeks
Li
1998
154
RCT
China
Isosorbide dinitrate
0.2 g tid
10# tid
ECG and symptom
8 weeks
Feng and Zhou
2000
500
RCT
China
Salvia
10# tid
10# tid
ECG and symptom, Lipid profile and hemorheology
4 weeks
Mei
2000
128
RCT
NR
NR
China
Isosorbide dinitrate
6# tid
10# tid
ECG, symptom, and hemorheology
4 weeks
Xiao
2000
138
RCT
NR
NR
China
Isosorbide dinitrate
5# tid
10# tid
ECG and symptom
4 weeks
Ru
2000
90
RCT
45–70
NR
China
Salvia
5# tid
3# tid
ECG, symptom, lipid profile, and hemorheology
Unclear
Shu
2000
80
RCT
China
Isosorbide dinitrate
10# tid
10# tid
ECG and symptom
4 weeks
Yong
2000
148
RCT
45–72
47–70
China
Nitroglycerin
10#
5 mg
ECG, Symptom, blood pressure, and heart rate
Immediately
Guang
2000
248
RCT
NR
NR
China
Isosorbide dinitrate
5# tid
10# tid
Blood pressure, heart rate, and lipid profile
4 weeks
Li
2000
166
RCT
NR
NR
China
Nitroglycerin
5# tid
0.5 mg
ECG and symptom
2 weeks
Yu
2000
184
RCT
40–82
NR
China
Isosorbide dinitrate
5# tid
10# tid
ECG and symptom
15 days
Ya
2000
60
RCT
60–84
61–84
China
Nitroglycerin
5# tid
10# tid
ECG and symptom
4 weeks
Yuan
2000
102
RCT
China
Huoxin pills
5# tid
1# tid
ECG, symptom, and lipid profile
4 weeks
Duan and Yang
2002
80
RCT
42–79
41–75
China
Xinkeshu capsule
5# tid
4# tid
ECG, UCG, lipid profile, and hemorheology
4 weeks
Hai
2002
70
RCT
China
Isosorbide dinitrate
5# tid
10# tid
Symptom and hemorheology
4 weeks
Bu
2002
100
RCT
32–72
NR
China
Isosorbide dinitrate
4–6# tid
10–20# tid
ECG and symptom
Unclear
Pei
2003
102
RCT
56.1
55.2
China
Nitroglycerin
5# tid
Unclear
ECG, lipid profile, and hemorheology
8 weeks
Jin
2003
178
RCT
NR
NR
China
Isosorbide dinitrate
5# tid
20 mg qd
ECG, Symptom, lipid profile, and hemorheology
6 weeks
Ma
2004
116
RCT
China
Salvia
10# tid
3# tid
ECG, symptom, and hemorheology
4 weeks
Pei
2004
100
RCT
China
Xinkeshu capsule
6# tid
4# tid
ECG and symptom
4 weeks
Yue
2004
78
RCT
52–75
55–74
China
Placebo
5# tid
10# tid
ECG, UCG, and symptom
4 weeks
Hu
2004
80
RCT
China
Nitroglycerin
10# tid
0.5 mg tid
ECG and symptom
24 weeks
Zhu
2005
199
RCT
61.8
59.5
China
Glucose-insulin-potassium therapy
4–6# tid
Q2 d
ECG, symptom, and lipid profile
15 days
Wan
2005
64
RCT
NR
NR
China
Hesu pills
5# tid
1# tid
ECG and symptom
2 weeks
Shui
2006
73
RCT
43–78
45–76
China
Salvia
10# tid
10# tid
ECG and lipid profile
8 weeks
Cao and Zhang
2007
187
RCT
China
Salvia
6# tid
6# tid
ECG and symptom
2 weeks
Run
2007
90
RCT
NR
NR
China
Isosorbide dinitrate
10–15#
10 mg
ECG and symptom
Immediately
Wang
2008
60
RCT
China
Shexiang Baoxin pills
5# tid
1# tid
ECG and symptom
2 weeks
L. Wen
2009
88
RCT
56.7
56.8
China
Isosorbide dinitrate
5# tid
10# tid
ECG and symptom
8 weeks
Feng
2009
900
RCT
NR
NR
China
Salvia
6# tid
3# tid
ECG and symptom
4 weeks
S. L. Wen
2009
50
RCT
NR
NR
China
Tongxinluo pills
5# tid
4# tid
ECG and symptom
2 weeks
Guo
2012
60
RCT
42–70
43–73
China
Salvia
5# tid
3# tid
UCG and hemorheology
2 weeks
Qiao
2012
300
RCT
39–82
40–81
China
Salvia
5# tid
3# tid
ECG and symptom
4 weeks
Xin
2013
289
RCT
China
Standard therapy
10# tid
Blank
ECG and symptom
2 weeks
Long
2013
120
RCT
43–68
42–67
China
Standard therapy
10# tid
Blank
ECG and symptom
2 weeks
Li
2015
100
RCT
44–75
45–76
China
Salvia
6# tid
3# tid
ECG and symptom
4 weeks
NR: not reported; RCT: randomized controlled trial; tid: three times a day; Q4–6 h: every 4–6 h; Q8 h: every 8 h; ECG: electrocardiograph; UCG: ultrasound cardiogram; : tablet.