Review Article

Efficacy of Suxiao Jiuxin Pill on Coronary Heart Disease: A Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics of selected clinical trials included in the meta-analysis.

Author nameYearSample sizeStudy designAgeAgeCountryComparatorsDosage/frequency/cycleOutcomesFollow-up period
(treatment)(control)Suxiao jiuxin pillsComparators

He199548RCT42–6040–57ChinaSalvia4# tid3# tidHemorheology4 weeks

Song1995149RCTChinaSalvia5# tid3# tidECG, blood pressure, and heart rate4 weeks

Wang199660RCTNRNRChinaShexiang Baoxin pills5# tid3# tidECG and symptom2 weeks

Ke199672RCT45–7946–78ChinaNitroglycerin6# tid0.5 mg Q8 hECG and symptom4 weeks

Gao et al.1996147RCT36–8535–84ChinaNitroglycerin10#0.5 mgECG and symptomImmediately

Yun1996318RCT44–7644–75ChinaIsosorbide dinitrate6–10#
Q4–6 h
10# tidECG and symptom2 weeks

Li1998154RCTChinaIsosorbide dinitrate0.2 g tid10# tidECG and symptom8 weeks

Feng and Zhou2000500RCTChinaSalvia10# tid10# tidECG and symptom, Lipid profile and hemorheology4 weeks

Mei2000128RCTNRNRChinaIsosorbide dinitrate6# tid10# tidECG, symptom, and hemorheology4 weeks

Xiao2000138RCTNRNRChinaIsosorbide dinitrate5# tid10# tidECG and symptom4 weeks

Ru200090RCT45–70NRChinaSalvia5# tid3# tidECG, symptom, lipid profile, and hemorheologyUnclear

Shu200080RCTChinaIsosorbide dinitrate10# tid10# tidECG and symptom4 weeks

Yong2000148RCT45–7247–70ChinaNitroglycerin10#5 mgECG, Symptom, blood pressure, and heart rateImmediately

Guang2000248RCTNRNRChinaIsosorbide dinitrate5# tid10# tidBlood pressure, heart rate, and lipid profile4 weeks

Li2000166RCTNRNRChinaNitroglycerin5# tid0.5 mgECG and symptom2 weeks

Yu2000184RCT40–82NRChinaIsosorbide dinitrate5# tid10# tidECG and symptom15 days

Ya200060RCT60–8461–84ChinaNitroglycerin5# tid10# tidECG and symptom4 weeks

Yuan2000102RCTChinaHuoxin pills5# tid1# tidECG, symptom, and lipid profile4 weeks

Duan and Yang200280RCT42–7941–75ChinaXinkeshu capsule5# tid4# tidECG, UCG, lipid profile, and hemorheology4 weeks

Hai200270RCTChinaIsosorbide dinitrate5# tid10# tidSymptom and hemorheology4 weeks

Bu2002100RCT32–72NRChinaIsosorbide dinitrate4–6# tid10–20# tidECG and symptomUnclear

Pei2003102RCT56.155.2ChinaNitroglycerin5# tidUnclearECG, lipid profile, and hemorheology8 weeks

Jin2003178RCTNRNRChinaIsosorbide dinitrate5# tid20 mg qdECG, Symptom, lipid profile, and hemorheology6 weeks

Ma2004116RCTChinaSalvia10# tid3# tidECG, symptom, and hemorheology4 weeks

Pei2004100RCTChinaXinkeshu capsule6# tid4# tidECG and symptom4 weeks

Yue200478RCT52–7555–74ChinaPlacebo5# tid10# tidECG, UCG, and symptom4 weeks

Hu200480RCTChinaNitroglycerin10# tid0.5 mg tidECG and symptom24 weeks

Zhu2005199RCT61.859.5ChinaGlucose-insulin-potassium therapy4–6# tidQ2 dECG, symptom, and lipid profile15 days

Wan200564RCTNRNRChinaHesu pills5# tid1# tidECG and symptom2 weeks

Shui200673RCT43–7845–76ChinaSalvia10# tid10# tidECG and lipid profile8 weeks

Cao and Zhang2007187RCTChinaSalvia6# tid6# tidECG and symptom2 weeks

Run200790RCTNRNRChinaIsosorbide dinitrate10–15#10 mgECG and symptomImmediately

Wang200860RCTChinaShexiang Baoxin pills5# tid1# tidECG and symptom2 weeks

L. Wen200988RCT56.756.8ChinaIsosorbide dinitrate5# tid10# tidECG and symptom8 weeks

Feng2009900RCTNRNRChinaSalvia6# tid3# tidECG and symptom4 weeks

S. L. Wen200950RCTNRNRChinaTongxinluo pills5# tid4# tidECG and symptom2 weeks

Guo201260RCT42–7043–73ChinaSalvia5# tid3# tidUCG and hemorheology2 weeks

Qiao2012300RCT39–8240–81ChinaSalvia5# tid3# tidECG and symptom4 weeks

Xin2013289RCTChinaStandard therapy10# tidBlankECG and symptom2 weeks

Long2013120RCT43–6842–67ChinaStandard therapy10# tidBlankECG and symptom2 weeks

Li2015100RCT44–7545–76ChinaSalvia6# tid3# tidECG and symptom4 weeks

NR: not reported; RCT: randomized controlled trial; tid: three times a day; Q4–6 h: every 4–6 h; Q8 h: every 8 h; ECG: electrocardiograph; UCG: ultrasound cardiogram; : tablet.