Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Fig 6

Research Article

PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment by Achyranthes bidentata

Figure 6

Structure predictions of quercetin, PIM-quercetin, CYP1B1-quercetin, and HSPA2-quercetin. (a) The secondary and tertiary structure of quercetin. (b) The 3D structures of PIM1 (left), CYP1B1 (middle), and HSPA2 (right). (c) The diagrams of protein-ligand interaction of PIM-quercetin (left), CYP1B1-quercetin (middle), and HSPA2-quercetin (right). The interactions were mediated by hydrogen bonding and hydrophobic contact. The dashed lines indicated hydrogen bonds; the arcs indicated hydrophobic contacts. Black dots represented carbon, red dots were oxygen, and blue dots were nitrogen. The black character labels were amino acids.

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