Studies on the Mechanism of Glutamate Metabolism in NTG-Induced Migraine Rats Treated with DCXF

Table 1

Summary of potential biomarkers.

Sample	Sort	Metabolites	Fold change M90/C	Fold change D90/C	Fold change F90/C
Serum	Common potential biomarkers	Isopentenyl pyrophosphate	2.3	1.05^##	1.34^##
		L-Asparagine	0.65	1.42^##	1.3^##
		Aminomalonic acid	0.59	1.1^##	0.98^##
		21-Hydroxypregnenolone	37.92	288.2	152.31
		Fluorene	0.51	1.06^##	0.96^##
		5-Methoxytryptamine	0.69	2.41	1.72
		Beta-glycerophosphoric acid	0.59	1.2^#	1.47^##
		Farnesal	0.49	1.07^#	0.78^##
		Alpha-lactose	0.23	0.45	0.55^##
	Characteristic potential biomarkers for DCXF	Carnitine	1.69	3.05	1.66
		Capric acid	1.81	0.54^#	1.1
		3-Hydroxyphenylacetic acid	1.6	5.856	3.78
		Linoleic acid	0.48	1.04^#	0.55
	Characteristic potential biomarkers for FHC	Ribitol	1.46	2.45	2.3
		2(alpha-D-Mannosyl)-D-glycerate	4.44	157.23	8.11
		Arachidonic acid	0.6	0.67	0.94^##
		Palmitic acid	0.44	0.56	0.68
		Allose	0.59	0.95	1.08^##
		Beta-glycerophosphoric acid	0.57	0.77	0.96^#
		Alpha-tocopherol	0.35	0.46	0.88^##
		Glycerol	0.5	0.61	1.06^##
Brain tissue	Common potential biomarkers	Phosphoglycolic acid	1.62	1.21^#	1.04^#
		D-erythrose 4-phosphate	1.56	1.17^#	0.99^##
		Erythrose	1.40	0.97^#	1.99
		Inosine	1.64	1.10^##	0.95^##
		3,3′,4′5-Tetrahydroxystilbene	1.52	0.68^#	2.18
		Hydroxyatrazine	1.65	1.16^##	0.53^##
	Characteristic potential biomarkers for DCXF	Carnitine	1.89	1.34^##	2.56
		Fluorene	1.80	1.27^##	2.24
		Citric acid	1.61	1.05^##	1.23
		Succinic acid	1.38	1.11^##	1.61
		Adenine	1.43	1.18^#	1.46
	Characteristic potential biomarkers for FHC	Glyceric acid	1.76	1.58	0.46
		D-glucose	0.71	0.7	1.04^#
		N-formyl-L-methionine	1.60	1.29	1.17^##
		Alpha-linolenic acid	2.11	1.97	1.21^#
		Trehalose 6-phosphate	1.83	1.58	1.22^#
		Prostaglandin A2	6.74	6.99	1.14^#

Compared with the control group, , ; compared with the M90 group, , .