Intestinal Absorption Profile of Three Polygala Oligosaccharide Esters in Polygalae Radix and the Effects of Other Components in Polygalae Radix on Their Absorption
Table 2
Absorption parameters of SA5, SA6, and DISS in the intestines of rats (; n = 5).
Compound
Concentration (mg/ml)
(μg·cm−2·min−1)
(×10−5cm/min)
(%)
SA5
0.025
0.0091 ± 0.0011
0.61 ± 0.070
2.59 ± 0.23
0.050
0.031 ± 0.0012
1.05 ± 0.039
4.33 ± 0.13
0.075
0.033 ± 0.0014
0.73 ± 0.032
3.16 ± 0.07
SA6
0.043
0.020 ± 0.0017
0.77 ± 0.065
3.29 ± 0.25
0.086
0.041 ± 0.0041
0.80 ± 0.079
3.64 ± 0.27
0.130
0.048 ± 0.0040,
0.62 ± 0.52
2.79 ± 0.11
DISS
0.099
0.015 ± 0.0005
0.26 ± 0.068
1.13 ± 0.05
0.198
0.032 ± 0.0015
0.27 ± 0.013
1.15 ± 0.04
0.296
0.049 ± 0.022
0.28 ± 0.079
1.18 ± 0.04
< 0.01 and < 0.05, compared with low dose; < 0.01 and < 0.05, compared with medium dose.