Phytochemical Analysis and Toxicity Study of Aristolochia paucinervis Rhizomes Decoction Used in Moroccan Alternative Medicine: Histopathological and Biochemical Profiles
Table 4
Results of Tukey test for comparisons between groups regarding lesions in the kidney (subacute toxicity).
Histopathology of kidney
control group vs. group 1
control group vs. group 2
control group vs. group 3
group 1 vs. group 2
group 1 vs. group 3
group 2 vs. group 3
Tubular necrosis
1
0.19
0.008
0.11
0.008
0.58
Hyaline necrosis
1
0.73
0.049
0.73
0.049
0.19
Coagulation necrosis
1
1
0.38
1
0.38
0.38
Inflammatory infiltrate
1
0.15
0.03
0.15
0.03
0.33
Extended coagulation
1
1
1
1
1
1
Altered tissue architecture
1
1
1
1
1
1
Cell vacuolization
1
1
0.35
1
0.35
0.53
Tubular degeneration
1
0.74
0.47
0.74
0.47
0.93
Cell congestion
1
0.22
0.06
0.22
0.06
0.52
Tubular atrophy
1
1
1
1
1
1
Interstitial fibrosis
1
1
1
1
1
1
Vascular dilation
1
1
0.009
1
0.009
0.009
Control: normal diet; group 1: normal diet + 0.5 g/kg/day extract; group 2: normal diet + 1 g/kg/day extract; group 3: normal diet + 1.5 g/kg/day extract. : significant at 5% level.
