Compound Phyllanthus urinaria L Inhibits HBV-Related HCC through HBx-SHH Pathway Axis Inactivation

Figure 4

CP decreased the mRNA expressions of HBx, SHH, PTCH-1, and GLI-1 in HepG2-HBx cells. The mRNA was measured when HepG2-HBx cells were treated with CP (70μg/ml; 35 μg/ml, respectively) and cyclopamine (70μM)　for 48 h using RT-PCR. < 0.001, compared with the group of HepG2-NC; ^#P < 0.05, ^##P < 0.01, and ^###P < 0.001, compared with the group of HepG2-HBx.

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