The Variant at TGFBRAP1 but Not TGFBR2 Is Associated with Antituberculosis Drug-Induced Liver Injury
Table 1
Demographic characteristics, clinical characteristics, and laboratory indicators of enrolled patients.
Group
Non-ATDILI (n = 628)
ATDILI (n = 118)
value
General data
Age (years)a
40.92 ± 15.72
42.85 ± 18.44
0.284
Gender (male/female)c
375 (59.71%)
253 (40.28%)
69 (58.47%)
49 (41.52%)
0.801
Smoking (no/yes)c
407 (64.80%)
221 (35.19%)
80 (67.79%)
38 (32.20%)
0.532
Drinking (no/yes)c
465 (74.04%)
163 (25.95%)
83 (70.33%)
35 (29.66%)
0.464
Tuberculosis subtype, n (%)
PTBc
520
82.80%
79
66.95%
<0.001
EPTBc
43
6.85%
15
12.71%
PTB and EPTBc
65
10.35%
24
20.34%
General symptoms (no/yes)c
135 (19.62%)
492 (80.37%)
23 (19.49%)
95 (80.51%)
0.567
Fever (no/yes)c
344 (54.78%)
284 (45.22%)
50 (42.37%)
68 (57.62%)
0.016
Weight loss (no/yes)c
367 (58.43%)
261 (41.56%)
82 (69.49%)
36 (30.50%)
0.036
Night sweat (no/yes)c
433 (68.94%)
195 (31.05%)
86 (72.88%)
32 (21.12%)
0.446
Fatigue (no/yes)c
462 (73.57%)
166 (26.43%)
85 (72.03%)
33 (27.97%)
0.716
Poor appetite (no/yes)c
374 (59.55%)
254 (40.45%)
69 (58.47%)
49 (41.52%)
0.859
Local infection (no/yes)c
134 (21.34%)
494 (78.66%)
24 (20.34)
94 (79.66%)
0.758
Laboratory examinations
Mean ± SD or p50 (p25–p75)
RBC (×1012/L)a
4.28 ± 0.68
4.31 ± 0.74
0.481
HB (g/L)a
122.06 ± 20.58
122.87 ± 22.11
0.717
HCT (L/L)a
0.36 ± 0.06
0.38 ± 0.06
0.069
PLT (×109/L)b
232.50 (172.75–297.25)
236.50 (184.00–321.75)
0.134
WBC (×109/L)b
6.51 (5.17–8.44)
6.57 (4.99–7.96)
0.761
Neutrophils (×109/L)a
5.10 ± 2.73
5.23 ± 2.89
0.631
Monocytes (×109/L)a
1.26 ± 0.62
1.29 ± 0.79
0.625
Lymphocytes (×109/L)a
0.50 ± 0.25
0.55 ± 0.29
0.099
Neutrophils (%)a
70.13 ± 11.54
70.49 ± 11.50
0.760
Monocytes (%)a
7.30 ± 2.37
7.74 ± 2.62
0.077
Lymphocytes (%)b
17.5 (12.18–25.68)
16.25 (12.58–25.58)
0.527
TBIL (μmol/L)b
8.70 (6.30–12.10)
10.05 (7.50–14.13)
0.002
DBIL (μmol/L)b
3.45 (2.50–5.40)
3.55 (2.38–5.60)
0.126
IBIL (μmol/L)b
4.80 (3.40–7.03)
5.70 (3.98–7.95)
0.049
ALT (IU/L)b
15.00 (10.00–21.00)
28.00 (15.75–38.00)
<0.001
AST (IU/L)b
19.50 (16.00–25.00)
27.00 (20.00–34.00)
<0.001
TP (g/L)a
68.82 ± 9.15
69.42 ± 8.42
0.508
ALB (g/L)a
37.89 ± 6.90
38.64 ± 7.35
0.248
GLB (g/L)a
30.93 ± 7.02
30.78 ± 6.65
0.829
GLU (mmol/L)b
5.14 (4.71–5.89)
5.15 (4.64–5.95)
0.41
UREA (mmol/L)b
4.05 (3.15–5.30)
3.92 (2.90–5.24)
0.299
CREA (μmol/L)b
60.45 (49.00–73.20)
57.50 (47.78–67.00)
0.601
CYS-C (mg/L)b
0.92 (0.79–1.06)
0.91 (0.81–1.04)
0.975
Uric (μmol/L)a
331.51 ± 155.30
291.29 ± 125.98
0.008
TG (mmol/L)b
1.06 (0.80–1.43)
0.99 (0.81–1.31)
0.469
CHOL (mmol/L)a
3.96 ± 1.058
3.96 ± 1.206
0.966
HDL-C (mmol/L)a
1.08 (0.82–1.41)
1.12 (0.85–1.48)
0.811
LDL-C (mmol/L)b
2.21 (1.69–2.77)
2.20 (1.79–2.72)
0.575
ALP (IU/L)b
79.00 (64.00–98.00)
85.50 (68.50–106.00)
0.021
GGT (IU/L)b
29.00 (19.00–48.00)
42.50 (26.00–78.00)
<0.001
CRP (mg/L)b
12.25 (2.67–37.43)
9.74 (2.30–39.23)
0.961
ESR (mm/h)b
33.50 (14.75–64.00)
38.50 (20.50–63.00)
0.173
Severity
N
Age (years)
Gender (N)
Male
Female
Mild
83
40.42 ± 16.48
0.888
53
30
0.117
Moderate
21
42.19 ± 14.04
11
10
Severe
14
41.57 ± 14.78
5
9
TB, tuberculosis; PTB, pulmonary tuberculosis; EPTB, extrapulmonary tuberculosis. aData are shown as mean ± standard deviation; bdata are shown as median (interquartile range); cdata are shown as number of cases (frequency).
