Research Article

The Variant at TGFBRAP1 but Not TGFBR2 Is Associated with Antituberculosis Drug-Induced Liver Injury

Table 3

Genetic models of related SNPs associated with ATDILI in tuberculosis patients.

GenedbSNPDominant modelRecessive modelAdditive model
OR (95% CI)OR (95% CI)OR (95% CI)

TGFBRAP1rs176877271.634 (1.076–1.634)0.0211.982 (0.620–6.335)0.2481.559 (1.083–2.246)0.017
rs757254261.073 (0.661–1.073)0.7740.900 (0.198–4.078)0.8911.047 (0.684–1.601)0.832
rs22417971.064 (0.716–1.064)0.7590.845 (0.390–1.833)0.6701.010 (0.740–1.377)0.951
rs25767360.793 (0.526–0.793)0.2680.908 (0.397–2.076)0.8190.847 (0.607–1.182)0.329
rs124767200.873 (0.562–0.873)0.5460.965 (0.608–1.532)0.8820.936 (0.708–1.237)0.643
rs26798760.816 (0.537–0.816)0.3420.632 (0.219–1.820)0.3950.820 (0.576–1.168)0.272

TGFBR2rs18355380.762 (0.479–1.211)0.2500.885 (0.195–4.007)0.8740.792 (0.519–1.209)0.280
rs98819451.078 (0.694–1.673)0.7371.142 (0.323–4.038)0.8361.073 (0.729–1.578)0.720
rs45228091.071 (0.722–1.589)0.7330.513 (0.216–1.219)0.1310.937 (0.688–1.276)0.682
rs119244220.922 (0.622–1.367)0.6850.911 (0.436–1.904)0.8050.934 (0.683–1.278)0.670
rs124936071.052 (0.707–1.565)0.8000.885 (0.452–1.734)0.7231.004 (0.743–1.356)0.978
rs18086020.964 (0.626–1.484)0.8690.732 (0.432–1.241)0.2460.893 (0.672–1.188)0.437
rs10789850.959 (0.619–1.487)0.8541.583 (0.572–4.376)0.3761.025 (0.706–1.488)0.896
rs98473680.864 (0.535–1.394)0.5491.066 (0.230–4.926)0.9350.891 (0.578–1.375)0.604
rs1143426390.929 (0.615–1.399)0.7210.811 (0.277–2.368)0.7010.924 (0.650–1.315)0.663
rs37736440.799 (0.534–1.195)0.2751.008 (0.583–1.742)0.9770.894 (0.669–1.196)0.452
rs37736521.199 (0.753–1.909)0.4441.277 (0.816–1.997)0.2831.176 (0.887–1.558)0.260
rs20431360.954 (0.624–1.459)0.8270.864 (0.496–1.508)0.6080.936 (0.696–1.26)0.665
rs8766881.188 (0.800–1.763)0.3921.98 (0.965–4.059)0.0621.259 (0.917–1.727)0.153

: value was calculated using logistic regression analysis.