Evidence-Based Complementary and Alternative Medicine

Evidence-Based Complementary and Alternative Medicine / 2019 / Article

Review Article | Open Access

Volume 2019 |Article ID 1704816 | 7 pages | https://doi.org/10.1155/2019/1704816

Top-100 Most Cited Publications Concerning Network Pharmacology: A Bibliometric Analysis

Academic Editor: Cheorl-Ho Kim
Received25 Apr 2019
Revised26 Jun 2019
Accepted01 Jul 2019
Published01 Aug 2019

Abstract

Background. Network pharmacology (NP) has become an increasingly important focus in the drug research field over the past decade. However, no study to date has mapped the current status of NP. Therefore, we performed a bibliometric study to evaluate the top 100 cited papers on NP. Methods. We searched the Web of Science Core Collection from its inception to February 25, 2019, using the terms “network pharmacology” and “systems pharmacology.” Key data, including title, publication year, number of citations, authors, countries/regions, organizations, and journals, were retrieved and analyzed using Excel 2016 and VOSviewer 1.6.10. Results. The total number of citations for the 100 cited papers ranged from 21 to 1,238, published in 53 journals, from 2005 to 2017. The top three journals with the most publications on NP were Clinical Pharmacology & Therapeutics (n = 8, IF2017 = 6.544), Journal of Ethnopharmacology (n = 8, IF2017 = 3.115), and PLoS One (n = 7, IF2017 = 2.766). Most published articles were from the USA (n = 41) and China (n = 35). The most active author was Wang Yonghua from the Northwest A&F University, and of the 100 publications, 14 listing his name. The most frequently used substantive terms included “drug discovery,” “traditional Chinese medicine (TCM),” “in-vitro,” “cancer,” and “cardiovascular disease.” Conclusions. The USA and China made the greatest contribution to NP research. The current NP research mainly focused on NP methods (including experimental validation) and using them to explore the molecular mechanisms of TCM for some critical diseases such as cardiovascular diseases and cancers. Furthermore, we believe some guidelines should be developed to regulate NP studies.

1. Introduction

Network pharmacology (NP, also well known as systems pharmacology) is a novel method for drug discovery, combining systems biology, omics, computational biology, and bioinformatics to explore the potential mechanisms of drug activity through conetwork analyses [13]. NP can help to understand the polypharmacology of a drug and its effect on biological networks to improve drug efficacy [4]. In traditional Chinese medicine (TCM), herbs used for disease treatment are also considered to have multiple targets and pathways [5, 6]. The advent of NP has afforded new methods to identify particular targets of the active complex ingredients of herbs used in TCM and their interactions in the context of molecular networks [1, 3, 5]. To date, two common options for conducting NP are used. The first method, classic NP, involves the downloading of hundreds of herbal compounds from a database, or combining literature, and the mapping of a body of targets [6]. The second method involves the integration of experimental data to validate the computational results [7, 8]. Recently, many studies on NP for TCM have been published in various journals [611]. For example, Gao et al. [8] employed the NP and experimental methods, and they found MMP2, CASP3, MYC, and REG1A to be important targets in the Kushen injection for hepatocellular carcinoma.

Bibliometrics studies use a set of methods to quantify published scientific knowledge [12, 13] and can be used to summarize the status quo and development trends of a specific disease or research field, providing ideas and directions for future research [14, 15]. Bibliometric approaches are commonly used in many research fields to map their foci and trends [1618]. The Web of Science Core Collection (WoSCC) is the most commonly used platform for bibliometric analyses [19]. To date, there has been no comprehensive review of studies on NP using bibliometric methods. Therefore, herein, we designed a bibliometric study to analyze the 100 most cited papers on NP using data from WoSCC. The data provide a holistic perspective on the research status of NP by analyzing the publication years, number of citations, authors, countries/regions, organizations, journals, and other key features of these papers. The workflow of the bibliometric study on NP research is shown in Figure 1.

2. Methods

2.1. Data Sources

The 100 most cited NP-related papers were retrieved from the WoSCC database, and the time span was set from its inception to February 25, 2019, at Lanzhou University, Lanzhou, Gansu, China. The data were obtained on the same day to avoid bias. The search strategy was as follows: TS = (“network pharmacology” OR “systems pharmacology”) with only publications indexed as “ARTICLE” or “REVIEW” being included. All hits were ranked by the number of citations to identify the top 100 cited papers.

2.2. Data Extraction

Two independent authors assessed each identified paper to ensure that the study referred to NP, and a third author corroborated the results. Information was collected by combining the reports from the WoSCC database and manual supplementation, including title, accession number, publication year, publication types, number of citations, authors, countries/regions, organizations, journals, and their impact factors (IFs).

2.3. Statistical Analysis

Microsoft Excel 2016 software was used for descriptive statistical analyses of the publication year, publication types, number of citations, authors, countries/regions, organizations, and journals and their IFs (from 2017 Journal Citation Reports of Clarivate Analytics). VOSviewer 1.6.10 [20] software was used to map the network of keyword co-occurrence (unit of analysis was set as “All keywords”). In the terms’ map, each bubble represented a term, the size of the bubble indicated how often it appeared. The color of a bubble indicated the special one cluster. If they appeared together in any of the 100 papers, a line connected the two bubbles; the thicker the line, the greater the number of times they appeared together. Furthermore, the greater the frequency of two terms appearing together, the closer the two bubbles would be. The terms map appears in at least three times of the 100 papers.

3. Results

The 100 most cited papers related to NP identified from the WoSCC included 62 original articles and 38 review articles. The total number of citations of a paper ranged from 21 to 1,238, with the average number of citations being 77.06 (7,706/100). Nearly one-fifth of articles (n = 18) had more than 100 citations and only one paper, published in Nature Chemical Biology (IF = 13.843) and authored by Andrew L Hopkins from the University of Dundee in 2008, was cited more than 1,000 times [1]. Supplementary Table S1 presents the data for the top 100 cited papers assessed in the present study.

3.1. Year of Publications

The papers included in the present study were all published between 2005 and 2017, but no studies from 2006 to 2007 were included. Therefore, the average number of years since 2005 was approximately 9. Furthermore, more than 10 published studies were found only in 2012, 2013, and 2014, with the greatest number of papers being published in 2014. Figure 2 presents the distribution of the top 100 cited papers related to NP.

3.2. Distribution of Countries/Regions

The 100 most cited papers related to NP research were contributed by 25 countries/regions (Table S1). We found 14 countries/regions contributed to at least 2 NP publications each (Table 1); the greatest number of publications originated from the USA (n = 41), followed by China (n = 35) and England (n = 11). Finland, Germany, and the Netherlands contributed the same number of papers (n = 4).


Country/regionRecord

USA41
China35
England11
Finland4
Germany4
Netherlands4
Sweden3
Australia2
Belgium2
Denmark2
France2
Italy2
Scotland2
Spain2

3.3. Distribution of Organizations

More than 100 organizations (Table S1) made contributions to NP research, with 17 organizations contributing to at least 3 NP publications each (Table 2). Northwest A&F University, China, published 14% of the top 100 studies and ranked first, followed by Icahn School of Medicine at Mount Sinai, USA (10%, 10/100), Chinese Academy of Sciences, China (9%, 9/100), Dalian University of Technology, China (7%, 7/100), China Academy of Chinese Medical Sciences, China (5%, 5/100), and Harvard University, USA (5%, 5/100).


OrganizationRecord

Northwest A&F University14
Icahn School of Medicine at Mount Sinai10
Chinese Academy of Sciences9
Dalian University of Technology7
China Academy of Chinese Medical Sciences5
Harvard University5
University of Helsinki4
Tsinghua University4
University of Manchester4
Peking University4
Beijing University of Chinese Medicine4
US-Food and Drug Administration3
University of Pittsburgh3
University of California San Diego3
University at Buffalo3
Northwestern University3
Hong Kong Baptist University3

3.4. Distribution of Authors

The list of authors that published at least 5 NP publications each is presented in Table 3, with a total of 11 such authors. At the leading position in this list was Wang Yonghua, from the Northwest A&F University, who published 14 of the top 100 papers, followed by Yang Ling from the Chinese Academy of Sciences, who published 9 papers. Meanwhile, 7 other authors of the 11 with 5 or 6 NP studies were from the same university, Northwest A&F University. The other two authors Li Yan and Iyengar Ravi were from Dalian University of Technology and Icahn School of Medicine at Mount Sinai, respectively, with 7 NP studies each.


AuthorOrganizationRecord

Wang YonghuaNorthwest A&F University14
Yang LingChinese Academy of Sciences9
Li YanDalian University of Technology7
Iyengar RaviIcahn School of Medicine at Mount Sinai7
Tao WeiyangNorthwest A&F University6
Xu XueNorthwest A&F University6
Zhou WeiNorthwest A&F University6
Wang XiaNorthwest A&F University5
Huang ChaoNorthwest A&F University5
Wang JinanNorthwest A&F University5
Li BohuiNorthwest A&F University5

3.5. Distribution of Journals

Overall, the top 100 cited papers on NP were published in 53 academic journals (Table S1). Table 4 summarizes the journals (n = 20) where at least two studies concerning NP were published. The IF range for these journals was from 2.064 (Evidence-Based Complementary and Alternative Medicine) to 50.167 (Nature Reviews Drug Discovery). Most of these are published in the USA (55%, 11/20) and England (35%, 7/20). Clinical Pharmacology & Therapeutics (IF2017 = 6.544) and Journal of Ethnopharmacology (IF2017 = 3.115) published the greatest number of papers (8%, 8/100), followed by PLoS One (7%, 7/100; IF2017 = 2.766) and Molecular Biosystems (5%, 5/100; IF2017 = 2.759).


JournalRecordCountry/regionImpact factor (2017)

Clinical Pharmacology & Therapeutics8USA6.544
Journal of Ethnopharmacology8Ireland3.115
PLoS One7USA2.766
Molecular Biosystems5England2.759
Evidence-Based Complementary and Alternative Medicine4USA2.064
Nucleic Acids Research4England11.561
Annual Review of Pharmacology and Toxicology3USA13.295
Current Pharmaceutical Design3United Arab Emirates2.757
Drug Discovery Today3England6.848
Analytical Chemistry2USA6.042
Bioinformatics2England5.481
Briefings in Bioinformatics2England6.302
Cancer Research2USA9.13
Chemistry & Biology2USA5.915
Expert Opinion on Investigational Drugs2England3.883
Nature Chemical Biology2USA13.843
Nature Reviews Drug Discovery2England50.167
PLoS Computational Biology2USA3.955
Science Translational Medicine2USA16.71
Wiley Interdisciplinary Reviews-Systems Biology and Medicine2USA3.709

3.6. Co-Occurrence of Keywords

In all, 61 terms appeared 3 times or more in the titles or abstracts of the top 100 papers related to NP (Figure 3). For example, “drug discovery” appeared 21 times; “traditional Chinese medicine” appeared 12 times, “in-vitro” appeared 9 times, “cancer” appeared 8 times, and “cardiovascular disease” appeared 5 times. Accordingly, the terms or phrases associated with NP are divided into six clusters, represented by six colors (azure, yellow, purple, green, light blue, and red). From the results of co-occurrences, current NP research was shown to be mainly focused on drug discovery, TCM, cardiovascular diseases, cancers, pathways, network analysis, gene expression, protein-protein interactions, oral bioavailability, and in vitro experiments, with these topics being regarded as the current research hotspots in the field of NP. The terms that appeared at least five times are listed in Table 5.


KeywordOccurrenceLink strength

Drug discovery2174
Network pharmacology1869
Systems pharmacology1564
Traditional Chinese medicine1246
Disease1028
Discovery926
Gene-expression918
In-vitro923
Cancer833
Database829
Mechanisms829
Systems biology828
Expression717
Biology618
Pharmacology616
Cardiovascular-disease528
Mass-spectrometry515
Myocardial-infarction521
Network517
Prediction521
Signaling pathways516
Therapy516

4. Discussion

Herein, we identified and analyzed the 100 most cited papers related to NP research published from 2005 to 2017. This bibliometric study aimed to evaluate the research status and trends in the field of NP research.

The USA, China, and England published more than 10 NP publications each, whereas a further 11 countries published only 2–4 NP studies each between 2005 and 2017. It is likely that the more common use of TCM in China than in other countries led to the larger number of studies published along with the fact that the USA and England have more advanced biotechnologies and broader cooperation. Northwest A&F University (China) contributed the most papers, likely due to its establishment of a TCM database, TCMSP [5], and the university may have a more profound research foundation. Furthermore, Professor Wang Yonghua from Northwest A&F University published the greatest number of papers and ranked the first in the all authors of top 100 cited papers.

The total number of citations for the top 100 cited papers ranged from 21 to 1,238, and only one paper was cited more than 1,000 times, considering that NP was the next paradigm in drug discovery [1]. Compared with the number of citations in other specialties [15, 21], this number of citations is very low, likely due to the relative novelty of the research topic. However, considering the importance of NP for the development of TCM and drug discovery, increasing the funding and number of researchers involved is of great importance for the development of NP. The top 100 cited papers were published in 53 journals, among which four journals (Clinical Pharmacology & Therapeutics, Journal of Ethnopharmacology, PLoS One, and Molecular Biosystems) published a total of 28 papers, almost one-third of the total number of papers. Furthermore, another large journal group of 16 journals published 39 of the 100 papers; the remaining papers were published by 33 other journals. Most of these journals are issued by the USA and England and are generally from the field of pharmacology or bioinformatics, on which NP research and current applications are focused.

According to the results of keyword co-occurrence, the 100 most cited papers covered the main topics of NP research, including its applications and common research methods. Drug discovery, TCM, cardiovascular diseases, cancers, pathways, network analysis, gene expression, protein-protein interactions, oral bioavailability, and in vitro experiments, being regarded as the current research hotspots. Similarly, Yeung et al. [22] analyzed 100 most cited papers in ethnopharmacology and highlighted the importance of traditional medicine in medicine and food science. Pathway and network analysis and protein-protein interactions are common methods for NP [68, 23]. Oral bioavailability [24] is an essential parameter for drug absorption and utilization; therefore, NP studies commonly use this alone or in combination with other parameters, including drug likeness, Caco-2 permeability, and drug half-life, as filters to select compounds from herbs [6, 7, 25]. Other methods, such as molecular docking, are also used in many NP studies [6, 23]. Tao et al. [26] used NP methods finding that Radix Curcumae and Fructus Gardeniae shared the common targets, demonstrated the synergistic effects of Radix Curcumae formula for cardiovascular diseases, and explained the prescription rule (Jun-Chen-Zuo-Shi) of TCM for diseases. Moreover, Lyu et al. [9] employed NP and experiment methods that found antiendothelial inflammation was the common mechanism of Danhong injection for stroke and coronary artery disease. Bing et al. [6] used NP methods to indicate that licochalcone a and beta-sitosterol in Fuzhengkangai were active compounds to overcome drug resistance. Gong et al. [25] found that TTR might be a potential treating target of hepatocellular carcinoma by using NP methods. Therefore, we can conclude that current NP research mainly focused on NP methods (including experimental validation) and using them to explore the molecular mechanisms of TCM for some critical diseases such as cardiovascular diseases and cancers. However, we found various existing designs and reports on NP, with some concerns regarding the development of NP due to the lack of guidelines on the design, conduct, interpretation, and reporting of NP studies. Additionally, similar to the early period of clinical medicine research, there is a lack of evidence-based medicine and its useful measures [2729], with a vast amount of inconsistent evidence leading to confusion for clinicians and researchers. Therefore, we suggest that corresponding methodological and reporting guidelines should be developed to regulate the design and reporting of NP studies.

Our study has some advantages. First, to the best of our knowledge, this is the first study using the bibliometric method to summarize the status and development of the top 100 cited papers related to NP. Second, the top 100 cited papers related to NP analyzed in this study could be considered as indispensable for NP development. Third, the key data were all retrieved by combining the reports from WoSCC database and manual supplementation, thus ensuring the accuracy and completeness of the data. However, it had limitations similar to those of other bibliometric studies, namely, the limited search involving only the WoSCC database, with other common medicine databases, such as PubMed, Embase, and Scopus, not searched. Thus, some influential papers may have been missed. However, we note that the WoSCC database is the most used database for bibliometric analysis [19]. Second, it is logical that the citation frequency of studies published earlier should be greater than that of recent studies, therefore introducing bias. Third, the citation frequency of papers is influenced by factors such as the journals’ IF, authors, and organizations; indeed, the academic influence of studies cannot be reflected only by the number of times they are cited.

5. Conclusion

A bibliometric study was performed for the top 100 cited papers related to NP. These papers were published from 2005 to 2017 in various journals. Based on results from bibliometric software and our prior knowledge, we found that the current NP research mainly focused on NP methods (including experimental validation) and using them to explore the molecular mechanisms of TCM for some critical diseases such as cardiovascular diseases and cancers. The USA and China published the most highly cited papers on NP. Professor Wang Yonghua from Northwest A&F University was the most published author. Generally, this bibliometric study provides, for the first time, insights into the historical developments and research status of NP studies, and we suggest that corresponding methodological and reporting guidelines should be developed to regulate the development of NP studies.

Disclosure

Cuncun Lu and Zhitong Bing are co-first authors.

Conflicts of Interest

All authors declare that they do not have potential conflicts of interest.

Supplementary Materials

Supplementary Table S1: the main data of the top 100 cited papers assessed in the present study. (Supplementary Materials)

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