Motherwort Injection for Preventing Postpartum Hemorrhage in Women with Vaginal Delivery: A Systematic Review and Meta-Analysis of Randomized Evidence

Table 2

Comparison of motherwort injection vs. oxytocin.

Outcomes	N(n)	Effect estimate (95%CI)	I^2	Interaction P
Blood loss within 2 hours after delivery (mL)
Overall	8 (1793)	-21.18 (-52.43, 9.98)	99%
Type of administration
Immediate administration	1 (600)	-87.60 (-92.32, -82.88)	—	<0.001
Consecutive administration	7 (1193)	-12.95 (-29.59, 3.69)	88%
Risk factor for PPH
No risk factor	6 (1513)	-70.71 (-74.78, -66.64)	98%	<0.001
High risk factor	1 (80)	39.00 (9.86, 68.14)	—
Unclear	1 (200)	-20.00 (-24.62, 15.38)	—
Blood loss within 24 hours after delivery (mL)
Overall	8 (1791)	-51.95 (-70.91, -32.99)	94%
Type of administration
Immediate administration	1 (600)	-89.70 (-93.84, -85.56)	—	<0.001
Consecutive administration	7 (1191)	-44.59 (-70.84, -18.35)	92%
Risk factor for PPH
No risk factor	6 (1511)	-80.63 (-84.42, -76.84)	96%	0.18
High risk factor	1 (80)	-57.00 (-88.64, -25.36)	—
Unclear	1 (200)	-85.00 (-92.07, -77.93)	—
Postpartum hemorrhage
Overall	4 (658)	0.82 (0.50, 1.35)	0%
Type of administration
Consecutive administration	4 (658)	0.82 (0.50, 1.35)	0%	—
Risk factor for PPH
No risk factor	3 (578)	0.73 (0.30, 1.78)	32%	0.78
High risk factor	1 (80)	0.88 (0.35, 2.18)	0%
Adverse events
Overall	6 (1529)	0.12 (0.08, 0.17)	57%
Type of administration
Immediate administration	1 (600)	0.10 (0.07, 0.15)	—	0.07
Consecutive administration	5 (929)	0.24 (0.10, 0.57)	0%
Risk factor for PPH
No risk factor	5 (1329)	0.04 (0.02, 0.08)	0%	0.01
Unclear	1 (200)	0.25 (0.07, 0.93)	—