Motherwort Injection for Preventing Postpartum Hemorrhage in Women with Vaginal Delivery: A Systematic Review and Meta-Analysis of Randomized Evidence

Table 3

Comparison of motherwort injection and oxytocin vs. oxytocin alone.

Outcomes	N(n)	Effect estimate (95%CI)	I^2	Interaction P
Blood loss within 2 hours after delivery (mL)
Overall	29 (6060)	-55.06 (-84.06, -26.06)	100%
Type of administration
Immediate administration	18 (4297)	-45.91 (-87.57, -4.25)	100%	0.33
Consecutive administration	11 (1763)	-69.93 (-93.59, -46.27)	99%
Risk factor for PPH
No risk factor	12 (3460)	-69.33 (-108.01, -30.64)	100%	0.007
High risk factor	6 (870)	-71.66 (-103.41, -39.92)	97%
Unclear	11 (1730)	-29.15 (-36.81, -21.49)	98%
Blood loss within 24 hours after delivery (mL)
Overall	27 (5710)	-85.57 (-94.26, -76.88)	95%
Type of administration
Immediate administration	17 (4043)	-93.61 (-109.52, -77.69)	98%	0.21
Consecutive administration	10 (1667)	-80.91 (-92.61, -69.21)	88%
Risk factor for PPH
No risk factor	11 (3206)	-80.90 (-94.98, -66.82)	96%	0.63
High risk factor	6 (870)	-84.72 (-98.01, -71.43)	61%
Unclear	10 (1634)	-91.82 (-109.22, -74.43)	96%
Postpartum hemorrhage
Overall	18 (4767)	0.29 (0.21, 0.39)	0%
Type of administration
Immediate administration	12 (3523)	0.30 (0.21, 0.42)	0%	0.62
Consecutive administration	6 (1244)	0.24 (0.12, 0.51)	0%
Risk factor for PPH
No risk factor	8 (2811)	0.29 (0.18, 0.44)	0%	0.97
High risk factor	5 (820)	0.27 (0.14, 0.51)	0%
Unclear	5 (1136)	0.31 (0.16, 0.57)	0%
Adverse events
Overall	21 (4793)	0.53 (0.40, 0.70)	54%
Type of administration
Immediate administration	15 (3653)	0.74 (0.54, 1.03)	0	<0.001
Consecutive administration	6 (1140)	0.19 (0.11, 0.33)	35%
Risk factor for PPH
No risk factor	10 (2987)	0.60 (0.42, 0.85)	77%	0.88
High risk factor	3 (350)	0.66 (0.18, 2.34)	—
Unclear	8 (1456)	0.51 (0.30, 0.87)	0%