Anti-Neuroinflammatory Effect of Jaeumganghwa-Tang in an Animal Model of Amyotrophic Lateral Sclerosis

Figure 2

Effect of JGT on neuroinflammation in the spinal cord of mice. Spinal cord lysates from non-transgenic mice (Non-Tg), mice (Tg), and JGT-treated mice (Tg + JGT) were immunoblotted with anti-Iba-1, anti-TLR4, and anti-TNF-α (a). Iba-1, TLR4, and TNF-α expression levels are higher in the spinal cord of transgenic mice than in the controls. JGT administration reduces the expression of Iba-1, TLR4, and TNF-α in the spinal cord compared with transgenic mice. Tubulin is used as a loading control. Quantification of immunoblots of Iba-1, TLR4, and TNF-α (b). Data are presented as mean ± standard error of mean ( p < 0.05; p < 0.01; p < 0.001). JGT, Jaeumganghwa-tang.

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