A 4-Week Repeated Oral Dose Toxicity Study of Ssanghwa-Tang in Crl:CD Sprague Dawley Rats

Table 2

Amounts of ten marker components in the SHT decoction at 0, 1, and 4 weeks by HPLC (n=3).

Compound	Amount (mg/extract g)									Source
	0 week			1 week			4 week
	Mean	SD (×10^−1)	RSD (%)	Mean	SD (×10^−1)	RSD (%)	Mean	SD (×10^−1)	RSD (%)
5-HMF	0.94	0.06	0.66	0.92	0.18	2.00	0.92	0.19	2.08	RRP
Albiflorin	1.69	0.23	1.37	1.64	0.14	0.88	1.65	0.17	1.06	PR
Paeoniflorin	15.68	1.32	0.84	15.63	3.32	2.13	15.81	2.99	1.89	PR
Liquiritin apioside	3.51	0.41	1.18	3.41	0.56	1.64	3.52	0.52	1.48	GRR
Liquiritin	0.88	0.15	1.72	0.86	0.14	1.65	0.85	0.07	0.85	GRR
Ferulic acid	0.51	0.03	0.68	0.49	0.13	2.65	0.49	0.04	0.78	CR
Nodakenin	1.83	0.30	1.64	1.86	0.17	0.94	1.83	0.20	1.09	AGR
Coumarin	0.14	0.04	2.52	0.15	0.02	1.33	0.14	0.02	1.69	CC
Cinnamic acid	0.09	0.00	0.48	0.09	0.01	0.84	0.09	0.01	0.65	CC
Glycyrrhizin	7.00	0.56	0.81	7.00	0.84	1.20	6.95	1.99	2.86	GRR

RRP: Rehmanniae Radix Preparata; PR: Paeoniae Radix; GRR: Glycyrrhizae Radix et Rhizoma; CR: Cnidii Rhizoma; AGR: Angelicae Gigantis Radix; CC: Cinnamomi Cortex.