A 4-Week Repeated Oral Dose Toxicity Study of Ssanghwa-Tang in Crl:CD Sprague Dawley Rats

Table 3

Mortality and clinical signs in rats treated with SHT for 4 weeks.

Group	Dosing phase
	1 day	≤1 weeks	≤2 weeks	≤4 weeks	Final
Male
0 mg/kg/day	0	0	0	0	0/5	0/5
1000 mg/kg/day	0	0	0	0	0/5	0/5
2000 mg/kg/day	0	0	0	0	0/5	0/5
5000 mg/kg/day	0	0	0	0	0/5	5/5
Female
0 mg/kg/day	0	0	0	0	0/5	0/5
1000 mg/kg/day	0	0	0	0	0/5	0/5
2000 mg/kg/day	0	0	0	0	0/5	0/5
5000 mg/kg/day	0	0	0	0	0/5	0/5

Number of animals with dead animals/total animal number.
Number of animals with sign animals/total animal number.