Ozone Exerts Cytoprotective and Anti-Inflammatory Effects in Cardiomyocytes and Skin Fibroblasts after Incubation with Doxorubicin

Figure 6

Anti-inflammatory properties of ozone at different concentrations on IL-1, IL-8, IL-6, TNF-α, MMP-2, and MMP-9 production by cardiomyocytes and skin fibroblasts (at a density of 1.2 × 10⁵ cells/well). Cells were treated with or without ozone (from 10 up to 50 μg/mL) for 5 h before exposure to doxorubicin at subclinical concentration (100 nM) for 12 h ; ; ns: not significant.