Protective Effects of Evodiamine against LPS-Induced Acute Kidney Injury through Regulation of ROS-NF-κB-Mediated Inflammation

Figure 3

Effects of EVO on proinflammatory cytokines in rats and in NRK-52E cells treated by LPS. Rats were intraperitoneally (i.p.) injected with EVO (10 and 20 mg/kg) 1 h after LPS treatment. Inflammation was evaluated by the determination of serum (a and b) and tissue (c and d) levels of proinflammatory cytokines, including TNFα (a and c) and IL-1β (b and d). NRK-52E cells were treated with 1 μg/ml LPS in the presence or absence of 10 and 20 μM EVO for 24h. Relative mRNA expression of TNFα (e) and IL-1β (f) was measured. #p<0.05 vs control group. ##p<0.05 vs LPS group.

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