| Botanical names | Part used | Extracts used/dosage | Model(s) used | Parameters estimated | Histopathology | References |
| 1. Acacia mellifera (Vahl) | Leaves | Ethanol (250 and 500 mg/kg) | CCl4-induced | AST, ALT, GGT, ALP, bilirubin, TP | Cured the tissue lesions | [21] |
| 2. Adansonia digitata L. | Fruit’s pulp | Methanol (100, 200 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin | Minimal necrosis and regeneration of hepatocytes compared with CCl4 | [22] |
| 3. Anogeissus leiocarpus (DC) Wall | Bark | Ethanol (200 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin, total protein, albumin | Less hepatocyte vacuolation and cellular regeneration | [23] |
| 4. Argemone Mexicana L. | Aerial parts | Methanol, aqueous (100, 200, and 400 mg/kg) | CCl4-induced | SGOT, SGPT, ALP | 100 mg/kg methanolic extract more effective in healing liver parenchyma than other doses; 400 mg/kg aqueous extract showed a good result than the corresponding dose of methanol extract | [24] |
| 5. Balanites aegyptiaca L. | Bark | Water, methanol (250 and 500 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin | Both extracts decrease centrilobular degenerative changes | [25] |
| 6. Cannabis sativa L. | Seeds | Petroleum ether (1 and 0.5 ml/kg) | CCl4-induced | AST, ALT, ALP, bilirubin | 1 ml/kg: showed scattered areas of necrosis of the hepatocytes | [26] | 0.5 ml/kg: showed slight areas of necrosis and slight fatty change |
| 7. Capparis decidua (Forsk.) | Stems | Aqueous, methanol (200 and 400 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin | Aqueous and methanolic extracts masked the liver fatty changes | [7, 27] | Branches | Methanol (12.5, 25, and 50 mg/kg) | CCl4-induced, paracetamol-induced | AST, ALT, ALP, bilirubin, total protein, albumin | — | [28] | Roots | Ethanol (200 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin, total protein, albumin | Less hepatocyte vacuolation and cellular regeneration | [23] |
| 8. Combretum hartmannianum (Schweinf) | Leaves | Methanol (12.5, 25, and 50 mg/kg) | CCl4-induced, paracetamol-induced. | AST, ALT, ALP, bilirubin, total protein, albumin | — | [28] |
| 9. Dobera glabra (Forsk.) | Leaves | Aqueous methanol (200 and 400 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin | Diffuse centrilobuar necrotic lesions in liver cells | [29] |
| 10. Khaya senegalensis (Desr.) | Bark | Aqueous (250 and 500 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin, total protein, albumin | 250 mg/kg: showed moderate necrosis of the hepatocytes and vacuolations | [30, 31] | 500 mg/kg: almost mild fatty changes in livers | Bark | Ethanol (200 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin, total protein, albumin | Mild histopathological changes in the liver | [23] | Bark | Methanol (12.5, 25, and 50 mg/kg). | CCl4-induced | AST, ALT | — | [32] | Bark | Methanol (50 mg/kg) | paracetamol-induced | AST, ALT, ALP, bilirubin, total protein, albumin | Section of methanolic extract-treated rats showing few vacuolation, reduced sinusoidal dilatation, and no congestion | [33] |
| 11. Kigelia africana Lam. | Seeds | Aqueous (400 mg/kg), methanol (100, 200, and 400 mg/kg) | CCl4-induced | AST, ALT, ALP | Cytoplasmic fatty vacuolation, haemorrhages, and necrosis of the centrilobular hepatocytes | [34] |
| 12. Lawsonia inermis L. | Leaves | Methanol (100 and 200 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin, total protein | Showed minimal necrosis and regeneration of hepatocytes compared with CCl4 | [35] |
| 13. Lepidium sativum L. | Seeds | Methanol (200 and 400 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin. | Mild-to-moderate changes in hepatocytes in both doses | [36] |
| 14. Moringa oleifera Lam. | Leaves | Aqueous (200 and 400 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin | Slight changes in liver cells | [37] |
| 15. Nigella sativa L. | Seeds | Methanol (250 and 500 mg/kg) | CCl4-induced | AST, ALT, ALP | Less centrilobular vacuolation and inflammatory cell infiltration. | [38] | Seeds | Aqueous (250 and 500 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin, total protein | Less hepatocyte changes | [30] | Seeds | Methanol (25, 50, 75, and 100 mg/mL) in vitro | Paracetamol-induced | Blood ions, ALT, AST, ALP, antioxidant enzymes, e.g., SOD, GSH, and MDA | Improvement of lesions observed in CCl4 such as necrosis, loss of hepatocytes architecture, and cellular infiltration | [39] | Methanol (100, 300, and 900 mg/kg) in vivo |
| 16. Occimum basilicum L. | Whole plant | Ethanol (200 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin, total protein, albumin | Less vacuolated hepatocytes and cellular regeneration | [40] |
| 17. Phoenix dactylifera Linn. | Pollen grain powder | Water (250 and 500 mg/kg) | CCl4-induced | AST, ALT, ALP | Mild changes in hepatocytes | [41] |
| 18. Raphanus sativus L. | Seeds | Methanol, water (200 and 400 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin | Mild-to-moderate changes in hepatocytes in both doses | [42] |
| 19. Solanum nigrum L. | Whole plant | Water, methanol (250 and 500 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin | Water: small vacuoles were seen in centrilobular hepatocytes. In methanol, slight changes in the fat content of hepatocytes were seen. | [43] |
| 20. Sterculia Setigera Del. | Bark | Ethanol, ethyl acetate (200 and 400 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin, total protein, albumin | Showed no stenosis (fatty changes in hepatocytes) and perivenular fibrosis compared with the CCl4 group. | [44] |
| 21. Tamarindus indica L. | Fruit’s pulp | Ethanol (150 mg/kg) | CCl4-induced | AST, ALT, ALP, bilirubin | Showed slight fatty changes | [45] |
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