A Chinese Prescription Chuanxiong Chatiao San for Migraine: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 1

(a) Basic characteristic of included studies

Study	Diagnostic standard	Drug; E/C		Case; E/C	Sex; E/C		Ages; E/C
Hu 2018 [18]	NR	Chuanxiong Chatiao san; 86g; 200ml/day	Nimodipine tablets; 120mg/day	43/43	23/20	22/21	36.83	37.57
Sun 2016 [14]	ICHD-II; 2004	Chuanxiong Chatiao san; 85g; 200ml/day	Flunarizine hydrochloride capsules; 10mg/day	60/60	NR	NR	NR	NR
Wang 2015 [19]	ICHD-II∖TCGNCM	Chuanxiong Chatiao san; 166g	Flunarizine hydrochloride capsules; 10mg/day	40/40	15/25	11/29	33.5	34.30
Zhao 2014 [20]	CDSS	Chuanxiong Chatiao san; 105g	Flunarizine hydrochloride capsules; 5mg/day	60/60	44/76		42
Liu 2014 [21]	STCMDE	Chuanxiong Chatiao san; 133g; 400ml/day	Flunarizine hydrochloride capsules; 10mg/day	35/30	10/25	10/20	37.5	37
Wu 2014 [22]	NR	Chuanxiong Chatiao san; 109g	Flunarizine hydrochloride capsules; 10g/day	23/23	5/18	3/20	48	41
Yuan 2012 [23]	PN; ∖TCGNCM	Chuanxiong Chatiao san; 68g; 300ml/day	Flunarizine hydrochloride capsules; 10mg/day	46/40	14/32	10/30	32.58	34.46
Guo 2012 [17]	ICHD-II	Chuanxiong Chatiao san; 80g	Flunarizine hydrochloride capsules; 10mg/day	60/60	22 /38	27/33	52.5	55
Zhang 2012 [24]	ICHD-II∖STCMDE	Chuanxiong Chatiao san; 114g	Flunarizine hydrochloride capsules; 10mg/day	40/40	12/28	11/29	36.5	38.1
Mao 2013 [25]	ICHD-II	Chuanxiong Chatiao san; 105g	Flunarizine hydrochloride capsules; 5mg/day	45/45	24/21	22/23	38.8	38.5
Xia 2010 [26]	DCTPIMC∖; STCMDE	Chuanxiong Chatiao san; 75g	Flunarizine hydrochloride capsules; 5mg/day	42/38	8/34	9/29	35	38
Fan 2010 [27]	NR	Chuanxiong Chatiao san; 149g	Flunarizine hydrochloride capsules; 10mg/day	50/50	30/20	33/17	NR	NR
Zhang 2017 [28]	IMTCM	Chuanxiong Chatiao san; 108g	Ibuprofen; 0.6g/day	45/40	6/34	8/37	35.9	35.5
Dong 2009 [29]	IHS; 1988	Chuanxiong Chatiao san; 146g	Nimodipine Tablets; 120mg/day diazepam; 7.5mg/day; Gammariza; 90mg/day	55/53	15/40	16/37	38.7	38.9
Li 2008 [30]	IHS; 1988	Chuanxiong Chatiao san; 118g; 300ml/day	Pizotifen Tablets; 0.5mg/day	134/134	61/73	59/75	34	34.6
Zhan 2007 [31]	IHS; 1988; ∖TCGNCM	Chuanxiong Chatiao san; 100g	Nimodipine Tablets; 60mg/day	60/22	22/38	9/13	38.2	37.5
Zhang 2006 [32]	IHS	Chuanxiong Chatiao san; 87g	Flunarizine hydrochloride capsules; 10g/day	32/30	5/27	6/24	37.96	36.63
Fu 2004 [33]	IHS; 1988	Chuanxiong Chatiao san	Paracetamol, Aspirin, Indometacin, Propranolol	138/138	166 /110		36.4	36.4
Shi 2002 [34]	PIM	Chuanxiong Chatiao san; 88g; 400ml/day	Flunarizine hydrochloride capsules; Nifedipine; 30mg/day	35/28	11/24	8/ 20	45.8	46.1

(b) Quality of included trials assessment

Study	Random method	Treatment/weeks	Withdrawal	Adverse events		follow-up	Outcome measures
Sun 2016 [14]	random number table	4	None	T:1	C:6	12 weeks	TER,VAS,5-HT,SP,β-EP
Hu 2018 [18]	randomized controlled	12	None	NR		NR	TER,VAS,AT; NE
Wang 2015 [19]	randomized controlled	2	None	T:1	C:3	NR	TER
Zhao 2014 [20]	randomized controlled	4	None	None		NR	TER
Liu 2014 [21]	randomized controlled	2	None	NR		NR	TER
Wu 2014 [22]	randomized controlled	2	None	NR		NR	TER
Yuan 2012 [23]	randomized controlled	4	None	None		NR	TER,GMP-140,TXB2, Hemorheology
Guo 2012 [17]	random number table	2	None	T:3	C:7	NR	TER
Zhang 2012 [24]	randomized controlled	4	None	NR		NR	TER
Mao 2013 [25]	randomized controlled	4	None	None		NR	TER
Xia 2010 [26]	randomized controlled	3	None	None		NR	TER,ABV
Fan 2010 [27]	randomized controlled	2	None	NR		NR	TER
Zhang 2017 [28]	randomized controlled	2	None	NR		NR	TER
Dong 2009 [29]	randomized controlled	4	None	NR		NR	TER, ABV
Li 2008 [30]	Odd even number distribution	4	None	NR		3 months	TER
Zhan 2007 [31]	randomized controlled	4	None	NR		NR	TER
Zhang 2006 [32]	randomized controlled	3	None	T:1	C:4	NR	TER
Fu 2004 [33]	randomized controlled	4	None	T:4	C:3	NR	TER,TD(integral), SP,DP
Shi 2002 [34]	randomized controlled	4	None	None		NR	TER

E, experiment group; C, control group; NR, not report.
IHS, International Headache Society. TCGNCM, The Clinical Guidelines for the New Chinese Medicine. CDSS, Clinical Diagnosis Symptoms of Study. STCMDE, Standard of TCM Diagnosis and Efficacy. PN, Practical Neurology. DCTPIMC, Diagnostic Criteria and Treatment Points of Internal Medical Diseases. HCN, Handbook of Clinical Neurology. IMTCM, Internal Medicine of Traditional Chinese Medicine. GFDTMC, Guidelines for diagnosis and treatment of migraine in China. HMNDT, Handbook of Modern Neurology Diagnosis and Treatment.
PIM, Practical Internal Medicine. TER, Total Efficacy Rate. ABV, average blood velocity in the brain. AT, analgesic time. HT, heal time. SP, systolic pressure. DP, diastolic pressure. SF, seizure frequency.
NE, number of episodes. ND, number of days of attack.
TD, time of duration.