Evidence-Based Complementary and Alternative Medicine

Review Article

A Chinese Prescription Chuanxiong Chatiao San for Migraine: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 2

(a) Basic characteristic of included studies


Study	Diagnostic standard	Drug E/C		Case E/C	Sex E/C		Ages E/C

Zheng2009	HCN∖IMTCM	Chuanxiong Chatiao san 63g 400ml/day +Flunarizine hydrochloride capsules 10mg/day	Flunarizine hydrochloride capsules 10mg/day	30/30	12/18	14/16	34.78	37.57

Sun2010	HMNDT∖IMTCM	Chuanxiong Chatiao san 63g 400ml/day +Flunarizine hydrochloride capsules 10mg/day	Flunarizine hydrochloride capsules 10mg/day	40/30	24/16	16/14	35	34.7

Meng2011	HMNDT∖IMTCM	Chuanxiong Chatiao san 63g 400ml/day +Flunarizine hydrochloride capsules 10mg/day	Flunarizine hydrochloride capsules 10mg/day	30/30	12 /18	14/16	34.75	34.72

Geng2011	IHS 1988	Chuanxiong Chatiao san 120g+ Nimodipine 90mg/day	Nimodipine 90mg/day Oryzanol 60mg/day	37/37	15/22	17/ 20	45.8	34.46

Liu2013	NR	Chuanxiong Chatiao san 400ml+Carbamazepine Tablets 0.2g/day	Carbamazepine Tablets 0.2g/day	42/42	15/27	16/26	63.72	52.64

Cao2014	HMNDT∖IMTCM	Chuanxiong Chatiao san 145g 400ml/day +Flunarizine hydrochloride capsules 10mg/day	Flunarizine hydrochloride capsules 10mg/day	30/30	NR	NR	NR	NR

Nie2015	Neurology/IMTCM	Chuanxiong Chatiao san 100g 400ml/day +Flunarizine hydrochloride capsules 10mg/day	Flunarizine hydrochloride capsules 10mg/day	58/59	16/42	15/44	33.07	33.25

Sun2015	Neurology/TCGNCM	Chuanxiong Chatiao san 135g 400ml/day +Flunarizine hydrochloride capsules 10mg/day	Flunarizine hydrochloride capsules 10mg/day	30/30	8/22	7/23	37.25	38.17

Wang2016	ICHD-III/TCGNCM	Chuanxiong Chatiao san 196g 400ml/day +Flunarizine hydrochloride capsules 10mg/day	Flunarizine hydrochloride capsules 10mg/day	20/20	NR	NR	18-65

Yuan2017	ICHD-ΙΙ	Chuanxiong Chatiao san 87g 400ml/day+ Nimodipine capsules 120mg/day	Nimodipine capsules 120mg/day	39/39	14/25	16/23	32	35

Zhang2017	TCGNCM	Chuanxiong Chatiao san 129g 500ml/day+ Nimodipine capsules 120mg/day	Naproxen 0.6g/day Flunarizine hydrochloride capsules 10mg/day	63/63	33/30	31/32	48.23	48.18

Liu2017	GFDTMC	Chuanxiong Chatiao san 153g/day +Flunarizine hydrochloride capsules 5mg/day	Flunarizine hydrochloride capsules 5mg/day	45/45	16/29	18/27	48.53	47.57

Wu2017	TCGNCM/ICHD-ΙΙ	Chuanxiong Chatiao san 68g/day +Flunarizine hydrochloride capsules 5mg/day	Flunarizine hydrochloride capsules 5mg/day	60/60	19/41	18/42	34.09	34.52

Ma2018	ICHD-ΙΙ	Chuanxiong Chatiao san 153g 400ml/day +Gabapentin 0.9g/day	Gabapentin 0.9g/day	43/43	27/16	29/14	43.21	43.86

Zuo2018	NR	Chuanxiong Chatiao san 63g 400ml/day +Flunarizine hydrochloride capsules 10mg/day	Flunarizine hydrochloride capsules 10mg/day	31/31	13/18	12/19	35.2	34.8

Cui2018	DCTPIMC	Chuanxiong Chatiao san +Flunarizine hydrochloride capsules 10mg/day	Flunarizine hydrochloride capsules 10mg/day	43/43	40/46		41.23

Zhao2018	DCTPIMC	Chuanxiong Chatiao san 153g+Flunarizine hydrochloride capsules 5mg/day	Flunarizine hydrochloride capsules 5mg/day	68/68	22/46	23/45	52.09	51.07

(b) Quality of included trials assessment


Study	Random method	Treatment/weeks	Withdrawal E/C	Adverse events E/C	follow-up	Outcome measures

Zheng2009	randomized controlled	4	None	None	NR	TER, ABV
Sun2010	randomized controlled	4	None	None	NR	TER, ABV
Meng2011	randomized controlled	4	None	None	NR	TER
Geng2011	randomized controlled	4	None	None	NR	TER
Liu2013	randomized controlled	4	None	NR	6 months	TER
Cao2014	randomized controlled	4	None	NR	NR	TER
Nie2015	randomized control method	4	2/1	None	1 months	VAS, NE,ND,TD
Sun2015	randomized controlled	4	None	NR	NR	TER,NE,TD
Wang2016	random number table	4	1/2	1/2	3 months	TER,VAS,TD,NE,ET-1,CGRP
Yuan2017	randomized controlled	7	None	NR	6 months	TER,VAS,AT,NE
Zhang2017	random number table	4	None	NR	NR	TER
Liu2017	randomized controlled	4	None	NR	1 months	TER, VAS
Wu2017	random number table	4	None	NR	6 months	TER, GMP-140, TXB2, 5-HT, CGRP, ABV
Ma2018	random number table	2	None	4/3	NR	TER,VAS, PSQI
Zuo2018	randomized controlled	6	None	NR	6 months	TER,VAS,NE,AT
Cui2018	random number table	8	None	NR	3 months	TER,5-HT,β-EP,SP
Zhao2018	randomized controlled	4	None	NR	1 months	TER,TD,

E, experiment group; C, control group; NR, not report.
IHS, International Headache Society. TCGNCM, The Clinical Guidelines for the New Chinese Medicine. CDSS, Clinical Diagnosis Symptoms of Study. STCMDE, Standard of TCM Diagnosis and Efficacy. PN, Practical Neurology. DCTPIMC, Diagnostic Criteria and Treatment Points of Internal Medical Diseases. HCN, Handbook of Clinical Neurology. IMTCM, Internal Medicine of Traditional Chinese Medicine. GFDTMC, Guidelines for diagnosis and treatment of migraine in China. HMNDT, Handbook of Modern Neurology Diagnosis and Treatment.
PIM, Practical Internal Medicine. TER, Total Efficacy Rate. ABV, average blood velocity in the brain. AT, analgesic time. HT, heal time. SP, systolic pressure. DP, diastolic pressure. SF, seizure frequency.
NE, number of episodes. ND, number of days of attack.
TD, time of duration.