Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 3

Research Article

The Tissue Distribution of Four Major Coumarins after Oral Administration of Angelicae Pubescentis Radix Extract to Rats Using Ultra-High-Performance Liquid Chromatography

Table 3

The concentrations of columbianetin, columbianetin acetate, osthole, and columbianadin in tissues (ng/mL)(n=6).

Tissuescolumbianetincolumbianetin acetateostholecolumbianadin
4h6h8h4h6h8h4h6h8h4h6h8h

Heart735.0±316.5814.6±192.386.9±80.277.4±41.2175.0±50.045.3±40.7183.5±56.0227.4±39.3135.5±28.60.00±0.0054.3±36.80.0±0.0
Liver1467.0±913.42032±514325.4±262.5183.3±22.21677.0±42.494.0±86.4669.3±286.51352±529.0257.8±24.3273.2±185.4908.4±738.646.8±51.3
Spleen533.1±266.9529.1±243.6171.0±9.947.4±30.6180.9±0.042.8±53.4191.2±48.5206.6±67.6153.5±42.60.00±0.000.00±0.0012.2±24.4
Lung653.0±306.1647.4±227.595.3±72.076.6±46.994.5±70.916.9±17.7275.0±101.6188.3±49.0125.8±24.70.00±0.000.00±0.000.0±0.0
Kidney810.3±460.5933.7±295.8222.1±41.5104.7±45.7180.9±0.050.5±40.9221.2±86.1264.1±19.6162.5±38.2136.3±60.90.00±0.00142.2±47.4
Uterus565.1±129.8582.6±130.5155.1±34.8140.5±49.2428.3±47.077.7±76.9261.0±57.0382.6±83.5167.0±42.3133.7±44.60.00±0.000.00±0.00
Ovary614.6±341.2604.9±132.291.4±16.3204.8±42.6292.9±145.098.6±38.8358.5±78.3403.5±97.6224.0±20.2118.7±68.5126.0±9.70.00±0.00
Muscle712.2±176.4663.3±239.3117.4 ±92.855.0±10.779.7±49.432.9±31.7154.7±9.7118.1±82.9126.4±7.00.00±0.000.0±0.00.00±0.00