The Tissue Distribution of Four Major Coumarins after Oral Administration of Angelicae Pubescentis Radix Extract to Rats Using Ultra-High-Performance Liquid Chromatography

Table 3

The concentrations of columbianetin, columbianetin acetate, osthole, and columbianadin in tissues (ng/mL)(n=6).

Tissues

columbianetin

columbianetin acetate

osthole

columbianadin

4h

6h

8h

4h

6h

8h

4h

6h

8h

4h

6h

8h

Heart

735.0±316.5

814.6±192.3

86.9±80.2

77.4±41.2

175.0±50.0

45.3±40.7

183.5±56.0

227.4±39.3

135.5±28.6

0.00±0.00

54.3±36.8

0.0±0.0

Liver

1467.0±913.4

2032±514

325.4±262.5

183.3±22.2

1677.0±42.4

94.0±86.4

669.3±286.5

1352±529.0

257.8±24.3

273.2±185.4

908.4±738.6

46.8±51.3

Spleen

533.1±266.9

529.1±243.6

171.0±9.9

47.4±30.6

180.9±0.0

42.8±53.4

191.2±48.5

206.6±67.6

153.5±42.6

0.00±0.00

0.00±0.00

12.2±24.4

Lung

653.0±306.1

647.4±227.5

95.3±72.0

76.6±46.9

94.5±70.9

16.9±17.7

275.0±101.6

188.3±49.0

125.8±24.7

0.00±0.00

0.00±0.00

0.0±0.0

Kidney

810.3±460.5

933.7±295.8

222.1±41.5

104.7±45.7

180.9±0.0

50.5±40.9

221.2±86.1

264.1±19.6

162.5±38.2

136.3±60.9

0.00±0.00

142.2±47.4

Uterus

565.1±129.8

582.6±130.5

155.1±34.8

140.5±49.2

428.3±47.0

77.7±76.9

261.0±57.0

382.6±83.5

167.0±42.3

133.7±44.6

0.00±0.00

0.00±0.00

Ovary

614.6±341.2

604.9±132.2

91.4±16.3

204.8±42.6

292.9±145.0

98.6±38.8

358.5±78.3

403.5±97.6

224.0±20.2

118.7±68.5

126.0±9.7

0.00±0.00

Muscle

712.2±176.4

663.3±239.3

117.4 ±92.8

55.0±10.7

79.7±49.4

32.9±31.7

154.7±9.7

118.1±82.9

126.4±7.0

0.00±0.00

0.0±0.0

0.00±0.00