Research Article

The Herb-Drug Pharmacokinetic Interaction of Fluoxetine and Its Metabolite Norfluoxetine with a Traditional Chinese Medicine in Rats by LC-MS/MS

Table 2

Intraday and interday precision of the analytes (n = 5).

CompositionConcentration (ng/ml)Intraday precisionInterday precision
Measured (ng/ml)RSD%Measured (ng/ml)RSD%

FLU10.980 ± 0.0232.350.964 ± 0.0262.70
43.974 ± 0.1974.963.958 ± 0.1874.72
1615.922 ± 0.7454.6815.836 ± 0.8155.15

NOF21.932 ± 0.0643.311.884 ± 0.0563.00
43.931 ± 0.1473.743.941 ± 0.1353.42
87.911 ± 0.3324.207.881 ± 0.3424.34

FLU: fluoxetine; NOF: norfluoxetine.