Yangyin Yiqi Mixture Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats through Inhibiting TGF-1/Smad Pathway and Epithelial to Mesenchymal Transition

Figure 3

Masson’s staining of lung tissues (200x). (a) Control group treated by normal saline on days 14. (b) Control group treated by normal saline on days 28. (c) BLM group induced pulmonary fibrosis and treated by normal saline on days 14. (d) BLM group induced into pulmonary fibrosis and treated by normal saline on days 28. (e) BLM + Pred group treated by prednisone on days 14. (f) BLM + Pred group treated by prednisone on days 28. (g) BLM + YYYQ-L group treated by low dose of YYYQ on days 14. (h) BLM + YYYQ-L group treated by low dose of YYYQ on days 28. (i) BLM + YYYQ-M group treated by middle dose of YYYQ on days 14. (j) BLM + YYYQ-M group treated by middle dose of YYYQ on days 28. (k) BLM + YYYQ-H group treated by high dose of YYYQ on days 14. (l) BLM + YYYQ-H group treated by high dose of YYYQ on days 28.

(a) Control 14d

(b) Control 28d

(c) BLM 14d

(d) BLM 28d

(e) BLM+ Pred 14d

(f) BLM+ Pred 28d

(g) BLM+ YYYQ-L 14d

(h) BLM+ YYYQ-L 28d

(i) BLM+ YYYQ-M 14d

(j) BLM+ YYYQ-M 28d

(k) BLM+ YYYQ-H 14d

(l) BLM+ YYYQ-H 28d