Yangyin Yiqi Mixture Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats through Inhibiting TGF-1/Smad Pathway and Epithelial to Mesenchymal Transition

Table 3

Data of ELISA assay of each group on day 14 and 28 were presented as mean± SD. Compared with control group (p <0.05, p <0.01), compared with BLM group (p <0.05, p <0.01), compared with BLM + Pred group (p <0.05, p <0.01), and compared with BLM + YYYQ-L group (p <0.05, p <0.01).

Group	TGF-β1	CTGF	Interleukin-18	Hydroxyproline
14d
Control	498.52±219.73	75.81±6.25	14.71±8.99	9.17±3.40
BLM	1282.41±527.68	197.08±67.21	27.29±5.86	22.20±6.76
BLM+ Pred	910.99±573.65	167.48±87.06	22.58±8.19	16.64±2.10
BLM+YYYQ-L	593.06±194.64	165.50±58.84	26.09±3.62	13.63±4.78
BLM+YYYQ-M	622.92±211.11	133.57±60.70	22.47±7.85	13.73±5.46
BLM+YYYQ-H	529.98±360.52	139.80±69.29	20.39±5.78	14.05±4.86
28d
Control	461.20±185.66	73.6±13.28	14.78±7.93	10.37±3.31
BLM	1246.48±256.99	204.17±20.16	24.79±7.12	26.40±5.48
BLM+ Pred	678.90±111.96	139.87±29.17	19.10±3.52	16.82±4.02
BLM+YYYQ-L	816.98±301.35	124.85±44.37	22.85±6.00	17.28±6.75
BLM+YYYQ-M	548.28±321.04	119.87±43.52	20.21±4.28	15.58±2.07
BLM+YYYQ-H	604.26±341.36	121.69±57.49	20.64±4.05	14.46±3.51