Yangyin Yiqi Mixture Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats through Inhibiting TGF-1/Smad Pathway and Epithelial to Mesenchymal Transition

Table 4

Data of real-time PCR assay of each group on day 14 and 28 were presented as mean± SD. Compared with control group (p <0.05, p <0.01), compared with BLM group (p <0.05, p <0.01), compared with BLM + Pred group (p <0.05, p <0.01), and compared with BLM + YYYQ-L group (△p <0.05, △△p <0.01).

Group	α-SMA	E-cadherin	Laminin	Collagen I
14d
Control	0.92±0.14	1.10±0.51	0.89±0.12	0.86±0.18
BLM	2.25±1.27	0.38±0.43	2.95±0.51	2.65±0.60
BLM+ Pred	1.74±0.58	0.44±0.39	2.02±0.59	2.37±1.28
BLM+YYYQ-L	1.49±0.29	0.71±0.16	1.90±0.57	2.08±1.20
BLM+YYYQ-M	1.31±0.66	0.80±0.40	1.66±0.10^##	1.78±0.46
BLM+YYYQ-H	1.43±0.17	0.91±0.51	1.47±0.42^##	1.62±0.64
28d
Control	0.96±0.09	1.23±0.41	0.83±0.16	0.79±0.15
BLM	2.69±0.59	0.33±0.29	3.23±0.45	3.28±1.15
BLM+ Pred	1.97±0.58	0.42±0.21	2.21±0.41	2.30±0.62
BLM+YYYQ-L	1.59±0.71	0.59±0.36	1.61±0.25	2.02±0.60
BLM+YYYQ-M	1.39±0.34	0.81±0.35	1.50±0.47	1.55±0.60
BLM+YYYQ-H	1.32±0.12	1.00±0.52	1.49±0.38	1.40±0.12