Yangyin Yiqi Mixture Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats through Inhibiting TGF-1/Smad Pathway and Epithelial to Mesenchymal Transition

Table 5

Data of real-time PCR assay of each group on day 14 and 28 were presented as mean± SD. Compared with control group (p <0.05, p <0.01), compared with BLM group (p <0.05, p <0.01), compared with BLM + Pred group (p <0.05, p <0.01), and compared with BLM + YYYQ-L group (△p <0.05, △△p <0.01).

Group	TGF-β1	TβRI	TβRII	Smad3	Smad7
14d
Control	1.08±0.16	1.00±0.17	1.06±0.08	0.61±0.27	1.21±0.31
BLM	2.39±0.77	3.02±0.79	3.10±0.63	2.31±0.76	0.63±0.13
BLM+ Pred	1.85±0.35	2.54±0.52	2.37±0.85	2.07±0.57	0.94±0.23
BLM+YYYQ-L	1.82±0.55	2.41±0.99	2.15±0.82	1.54±0.33	0.94±0.22
BLM+YYYQ-M	1.53±0.29	2.06±0.68	1.32±0.50	1.23±0.60	1.10±0.39
BLM+YYYQ-H	1.30±0.58	2.10±0.77	2.0±0.87	1.22±0.20	1.00±0.26
28d
Control	1.10±0.23	1.07±0.60	0.94±0.05	0.88±0.40	1.24±0.40
BLM	2.91±0.58	4.12±0.84	3.34±0.42	2.83±0.43	0.50±0.07
BLM+ Pred	1.69±0.10^##	2.80±0.67	1.84±0.24	2.18±0.32	0.97±0.27
BLM+YYYQ-L	1.62±0.59	2.54±0.46	2.14±0.54	1.54±0.52	1.04±0.44
BLM+YYYQ-M	1.40±0.24	1.94±0.60	1.57±0.85	1.25±0.31	1.23±0.30
BLM+YYYQ-H	1.19±0.43	1.60±0.46	1.34±0.88	1.51±0.62	1.08±0.20