Phyllanthus muellerianus (Euphorbiaceae) Restores Ovarian Functions in Letrozole-Induced Polycystic Ovarian Syndrome in Rats
Figure 1
Letrozole treatment of female rats resulted in reproductive and metabolic features of PCOS. (a) Blood glucose tolerance test; (b) body weight gain; (c, d) relative ovary and uterus weights, respectively; (e-g) ovarian LH, estradiol, and testosterone levels, respectively. Values are means ± SEM, number of animals per group =6. p<0.05; p<0.01; p<0.001: significantly different compared with control. (h) Section of ovary from a control rat showing growing follicles (at different stages) and a large number of corpus luteum. (i) Section of ovary from PCOS rats exhibiting many cystic and atretic follicles and decreased corpus luteum. CL: corpus luteum; CF: cystic follicle; AF: atretic follicle; PA: preantral follicle; A: antral follicle. Magnification x40. Calibration bar =100 μm.