MicroRNA in Acupuncture Studies: Does Small RNA Shed Light on the Biological Mechanism of Acupuncture?

Table 3

Changes of microRNAs by acupuncture treatment in the other disease animal models.

Disease model	Author	Year	Species	EA/MA	Acupoint	Acupuncture parameters	Tissue	Result
EA tolerance	Cui et al.	2017	Rat	EA	ST36, SP6	2 Hz/15 Hz,	Brain (hypothalamus)	↑ miR-124, miR-107,
						3mA, 30 min		↓ miR-148a, miR-370
Postoperative ileus	Deng et al.	2017	Rat	MA	ST36, SP6,	2-3 mm depth,	Colon	↓ miR-19a
					LR3	15 min
Chronic atrophic gastritis	Zhang et al.	2016	Rat	MA	ST36, CV20,	3 mm depth,	Gastric tissue	↑ miR-339,
					BL20	15 min		↓ miR-155, miR-21
Chronic kidney disease	Hu et al.	2015	Mouse	EA	GB34, ST36	20 Hz, 1 mA,	Muscle	↓ miR-1
						15 min
Hyperactivity of HPA axis	Zhu et al.	2017	Rat	EA	ST36, SP6	2 Hz/15 Hz,	Brain (hypothalamus)	↑ miR-142, miR-376c
						2mA, 30 min
Allergic contact dermatitis	Wang et al.	2018	Rat	EA	ST36	2 Hz, 1 mA,	Ear	↓ miR-155
						5 min, 20 min

EA; electroacupuncture, MA; manual acupuncture, HPA; hypothalamic-pituitary-adrenal.