Enhancing the Therapeutic Efficacy of Daunorubicin and Mitoxantrone with Bavachinin, Candidone, and Tephrosin

Figure 2

Effects of bavachinin, candidone, and tephrosin on the efflux of daunorubicin and mitoxantrone from MDR-resistant cells and their accumulation. MCF7/MX (a) and EPG85.257RDB (b) cells were treated with IC₁₀ of flavonoids for 24, 48, and 72 hrs. The data are presented as the mean of triplicate experiments ± SEM. The symbols , , , and represent values <0.05, <0.01, <0.001, and <0.0001, respectively. The Y-axis was plotted by log10 (a, 24 h).

(a)

(b)