Electroacupuncture Improves Antidepressant Effects in CUMS Rats by Protecting Hippocampal Synapse and Mitochondrion: An Ultrastructural and iTRAQ Proteomic Study

Figure 1

EA+SSRI accelerates depressed-like behaviors improvement in depressed rats. (a) Timeline of CUMS paradigm, interventions, and behavioral tests. (b) EA was performed at acupuncture point GV20 (Baihui) and GV29 (Yingtang). (c) EA and EA+SSRI increased body weight change caused by CUMS. (d) Both EA and EA+SSRI increased sucrose preference rate in depressed rats. EA+SSRI increased sucrose preference significantly. (e) EA and EA+SSRI increased central zone time spent in depressed rats significantly. (f) CUMS-induced total traveled distance decrease in open field was reversed by EA and EA+SSRI. EA+SSRI increased total traveled distance significantly (n=10-15 rats/group). (g) EA+SSRI reverses the hippocampal histopathology changes during CUMS (n=6 rats/group), × 400. Bar graphs represent mean ± SE. : P<0.05, : P<0.01, and : P<0.001 vs. CUMS. One-way ANOVA with LSD post hoc test.