Cytotoxic and Apoptotic Activity of Majoranolide from Mezilaurus crassiramea on HL-60 Leukemia Cells
Table 1
In vitro cytotoxicity () of ethanol extract and majoranolide obtained from fruits of Mezilaurus crassiramea, as tested against neoplastic and nonneoplastic cells.
Cells
Ethanol extract
Majoranolide
Doxorubicin
μg/mL
μg/mL
μM
μg/mL
μM
MCF-7
60.85±8.95
8.23±0.43
26.55±1.39
0.02±0.00
0.04±0.00
HT-29
>250
2.96±0.09
9.55±0.31
0.25±0.02
0.45±0.06
PC-3
>250
2.72±0.03
8.76±0.09
0.26±0.01
0.48±0.02
786-0
>250
22.73±0.35
73.26±1.15
0.02±0.00
0.04±0.00
MDA-MB-231
>250
24.36±0.18
78.51±0.58
0.19±0.01
0.36±0.02
HL-60
0.25±0.05
0.06±0.00
0.21±0.03
0.02±0.00
0.04±0.00
NIH/3T3
>250
70.61±10.97
227.59±35.37
0.29±0.02
0.54±0.04
GI50: concentration that inhibits cell growth by 50%. Doxorubicin was the positive control. Values represent means ± SD from three independent experiments.
