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Evidence-Based Complementary and Alternative Medicine
Volume 2019, Article ID 3494806, 8 pages
Research Article

Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression

1Department of Neuroscience, Korea University College of Medicine, 145, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea
2Food Science R&D Center, Kolmar BNH Co., LTD, 22-15, Sandan-gil, Jeonui-myeon, Sejong-si 30003, Republic of Korea

Correspondence should be addressed to Hyun Kyu Kim; rk.oc.hnbramlok@mikkh and Won-Ki Kim;

Received 17 July 2018; Revised 28 December 2018; Accepted 14 February 2019; Published 20 March 2019

Academic Editor: Raffaele Capasso

Copyright © 2019 Seul-Ki Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We determined the functional effect of the herbal preparation, HemoHIM, on the immune system, by examining the immunomodulatory activities of HemoHIM using immunocompromised mice. In this study, to examine the effect on the restoration of immune cells and balance in the immune system, we utilized a cisplatin-induced immunosuppression mouse model. Mice were injected intraperitoneally with cisplatin, an immunosuppressive anticancer, and then received oral doses of 100, 250, and 500 mg/kg of HemoHIM for 14 days. The HemoHIM prevented the cisplatin-induced loss of body and organ weight. In terms of innate immunity, natural killer (NK) cell activity and phagocytosis increased in the HemoHIM group compared to the cisplatin control group. The HemoHIM group also showed a significantly higher expression of Th1-mediated cytokines (interferon gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor alpha (TNF-α)) and inhibited the production of Th2-mediated cytokine interleukin-4 (IL-4) compared to cisplatin control group. These findings indicate that HemoHIM enhances immune activity by modulating immune cell activity and cytokine secretion in immune-suppressed mice.