In Vitro Anti-Inflammatory and In Vivo Antiarthritic Activities of Aqueous and Ethanolic Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Rats

Table 5

Effect of aqueous and ethanolic extracts of Dissotis thollonii on serum parameters in CFA-induced arthritis in rats.

Treatment	Dose (mg/kg)	ALT (U/I)	AST (U/I)	ALP (U/I)	Creatinine (μmol/l)	Total protein (g/dl)
Healthy control	—	47.09 ± 1.91	173.89 ± 11.61	90.27 ± 3.36	0.48 ± 0.07	7.45 ± 0.24
Arthritic control	—	77.88 ± 2.07^λ	423.09 ± 23.51^λ	444.38 ± 13.69^λ	1.39 ± 0.13^λ	5.90 ± 0.17^β
Diclofenac	5	63.46 ± 1.50^λc	250.70 ± 16.76^βc	240.11 ± 16.28^λc	0.93 ± 0.03^λc	6.65 ± 0.28
Aqueous extract	250	63.97 ± 1.72^λc	299.79 ± 11.76^λc	317.40 ± 17.20^λc	0.98 ± 0.05^λc	6.35 ± 0.34
	500	55.14 ± 1.16^αc	222.59 ± 6.07^c	207.33 ± 9.89^λc	0.69 ± 0.03^c	7.31 ± 0.19^a
Ethanolic extract	250	55.41 ± 1.84^αc	253.30 ± 2.77^βc	270.97 ± 7.43^λc	0.86 ± 0.3^βc	7.16 ± 0.29^a
	500	46.12 ± 1.42^c	177.62 ± 7.62^c	143.00 ± 5.34^c	0.60 ± 0.02^c	7.54 ± 0.28^b

CFA: complete Freund’s adjuvant; ALP: alkaline phosphatase; AST: aminotransferase; ALT: alanine aminotransferase. Each value represents the mean ± ESM for six animals and analyses by one-way ANOVA followed by Bonferroni post hoc test, ^α, ^β, ^λ when compared with the healthy control and ^a, ^b, ^c when compared with the arthritic control.