Integrated Metabolomics and Network Pharmacology Study on Immunoregulation Mechanisms of Panax ginseng through Macrophages

Table 2

The KEGG and GO pathway analysis.

Term	P value	Benjamini	Related proteins
KEGG Term
Glutathione metabolism	0.00079	0.025	P09211, P28161, P09488
Drug metabolism - cytochrome P450	0.0014	0.022	P09211, P28161, P09488
Metabolism of xenobiotics by cytochrome P450	0.0017	0.018	P09211, P28161, P09488
Chemical carcinogenesis	0.0019	0.015	P09211, P28161, P09488
Glycerophospholipid metabolism	0.08	0.41	P22303, P47712
Go Term (Biological Process)
glutathione derivative biosynthetic process	0.000034	0.0039	P09211, P28161, P09488
glutathione metabolic process	0.00023	0.013	P09211, P28161, P09488
cellular detoxification of nitrogen compound	0.0013	0.046	P28161, P09488
nitrobenzene metabolic process	0.0017	0.046	P28161, P09488
metabolic process	0.002	0.045	P09211, P28161, P09488
xenobiotic catabolic process	0.0029	0.053	P28161, P09488
linoleic acid metabolic process	0.0071	0.11	P09211, P28161
cellular oxidant detoxification	0.029	0.34	P09211, P28161
Go Term (Cellular Component)
cytosol	0.003	0.086	P11217, P09211, P28161, P30520, P09488, P47712
cytoplasm	0.024	0.3	P11217, P09211, P28161, P30520, P09488, P47712
extracellular exosome	0.079	0.56	P11217, P09211, P28161, P30520
Go Term (molecular function)
glutathione binding	8.1E-06	0.00033	P09211, P28161, P09488
glutathione transferase activity	0.000087	0.0018	P09211, P28161, P09488
acetylcholinesterase activity	0.00083	0.011	P22303, P06276
cholinesterase activity	0.0012	0.013	P22303, P06276
enzyme binding	0.0076	0.061	P28161, P09488, P06276
glutathione peroxidase activity	0.0087	0.058	P09211, P28161
beta-amyloid binding	0.014	0.079	P22303, P06276
protein homodimerization activity	0.034	0.16	P28161, P09488, P22303
transferase activity	0.039	0.17	P09211, P09488