Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models

Table 10

Hematological cytologic marker values of rats treated with CHB-II-F for 4 weeks in the sub-chronic toxicity test.

Parameters	Dose (g/kg)
	Control	26.20	13.10	6.55
Male
WBC (10^9/L)	4.95±0.84	5.77±0.99	4.85±0.96	4.62±1.14
Neu (%)	24.62±2.12	22.56±1.89	19.12±2.74	20.68±1.81
Lym (%)	67.06±2.25	69.50±1.05	72.50±2.74	71.36±1.79
Mon (%)	8.08±0.50	7.56±0.95	8.04±0.48	7.56±0.34
Eos (%)	0.04±0.04	0.02±0.02	0.06±0.04	0.04±0.02
Bas (%)	0.20±0.06	0.36±0.05	0.28±0.08	0.36±0.10
RBC (10^12/L)	7.049±0.32	6.88±0.33	7.38±0.12	7.06±0.53
HGB (g/L)	149.40±5.58	146.00±7.85	161.20±3.03	154.60±5.60
HCT (%)	38.64±1.55	38.26±1.56	42.14±0.99	39.94±1.56
MCV (fL)	54.86±1.11	55.46±0.52	57.06±0.56	56.54±0.75
MCH (pg)	21.22±0.15	21.20±0.24	21.82±0.15	21.88±0.35
MCHC (g/L)	386.60±2.57	382.40±4.42	382.80±3.50	387.00±2.54
PLT (10^9/L)	845.80±103.55	797.20±280.66	1145.40±65.12	909.00±165.48
Female
WBC (10^9/L)	2.03±0.55	2.70±0.42	4.60±0.91	3.75±1.22
Neu (%)	26.70±2.28	23.96±1.67	22.50±3.40	19.88±3.98
Lym (%)	65.16±2.0	67.46±1.43	69.16±3.02	70.98±3.14
Mon (%)	7.60±0.91	8.20±0.74	7.88±0.75	8.86±1.09
Eos (%)	0.08±0.06	0.02±0.02	0.02±0.02	0.04±0.04
Bas (%)	0.46±0.07	0.36±0.08	0.44±0.05	0.42±0.06
RBC (10^12/L)	6.62±0.33	6.52±0.20	7.06±0.13	6.87±0.21
HGB (g/L)	146.00±3.53	141.80±1.52	154.60±4.52	151.40±3.51
HCT (%)	37.52±1.08	38.48±0.84	39.56±1.05	39.70±0.51
MCV (fL)	56.86±1.35	59.12±1.53	55.98±0.44	57.76±0.85
MCH (pg)	22.16±0.65	21.78±0.50	21.88±0.25	22.04±0.31
MCHC (g/L)	389.20±4.54	369.00±7.04	390.60±2.50	381.20±3.53
PLT (10^9/L)	1088.40±40.52	1162.20±95.23	977.00±44.53	1022.60±84.33

Note: Data were presented as the mean ±SD from 12 rats. Statistical analysis: P < 0.05 compared with control group (untreated controls).