Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models

Table 12

Blood biochemical parameters of rats treated with CHB-II-F for 4 weeks in the sub-chronic toxicity test.

Parameters	Dose (g/kg)
	Control	26.20	13.10	6.55
Male
ALT (U/L)	46.20±3.01	46.20±4.59	36.40±1.56	41.75±2.53
AST (U/L)	80.00±3.57	76.60±4.53	79.75±5.37	83.80±5.54
ALB (g/L)	42.12±1.20	37.58±2.24	40.50±3.56	37.72±2.20
ALP (U/L)	173.00±21.57	196.50±18.11	166.40±30.62	156.60±16.25
TP (g/L)	70.00±0.52	64.80±0.88	70.20±0.88	72.00±2.58
BUN (mmol/L)	7.06±0.65	6.36±0.50	6.18±0.51	6.93±0.50
GLU (mmol/L)	7.04±0.53	6.96±0.22	6.53±0.33	6.82±0.26
TG (mmol/L)	0.24±0.05	0.29±0.55	0.52±0.09	0.33±0.55
TCHO (mmol/L)	1.92±0.06	1.52±0.08	1.82±0.12	1.91±0.053
CK (U/L)	267.00±45.18	262.75±42.19	298.00±51.52	271.60±45.37
CRE (μmmol/L)	29.46±1.55	28.86±1.52	31.32±1.60	27.80±1.49
CK-MB (U/L)	233.40±45.35	256.40±42.53	264.33±25.33	236.60±35.62
T-Bil (μmmol/L)	0.41±0.15	0.04±0.02	0.06±0.05	0.08±0.03
GGT (U/L)	0.20±0.22	0.60±0.45	0.40±0.25	0.40±0.25
K (mmol/L)	4.86±0.25	5.25±0.15	5.12±0.15	5.02±0.26
Na (mmol/L)	133.56±1.56	130.96±0.35	132.34±0.46	132.02±0.75
Cl (mmol/L)	109.24±1.24	107.42±0.35	109.04±0.51	110.38±0.35
Female
ALT (U/L)	38.00±5.23	45.40±5.34	38.80±3.51	43.40±4.56
AST (U/L)	77.20±3.52	73.60±2.15	75.00±2.54	77.75±2.53
ALB (g/L)	44.32±2.51	38.76±2.56	41.60±1.51	43.04±2.23
ALP (U/L)	87.00±8.96	94.40±8.64	66.40±4.26	113.00±16.25
TP (g/L)	75.60±5.36	68.60±0.51	72.40±1.52	76.60±2.59
BUN (mmol/L)	8.97±0.86	7.38±0.63	8.65±0.87	8.15±0.52
GLU (mmol/L)	8.39±0.76	9.02±0.26	7.95±0.51	7.53±0.75
TG (mmol/L)	0.32±0.07	0.26±0.09	0.33±0.05	0.31±0.04
TCHO (mmol/L)	1.91±0.23	1.83±0.11	1.54±0.15	1.76±0.09
CK (U/L)	188.60±15.61	196.20±17.25	165.75±8.25	147.24±9.25
CRE (μmmol/L)	37.84±1.89	37.44±2.58	35.30±1.72	37.84±2.58
CK-MB (U/L)	169.80±11.28	145.40±14.26	185.80±35.26	136.75±10.38
T-Bil (μmmol/L)	0.31±0.25	0.22±0.09	0.29±0.10	0.29±0.13
GGT (U/L)	0.20±0.22	0.60±0.25	0.20±0.22	0.80±0.42
K (mmol/L)	4.86±0.45	4.64±0.11	4.46±0.10	5.40±0.13
Na (mmol/L)	129.12±3.34	132.70±0.13	130.12±1.63	131.84±0.74
Cl (mmol/L)	110.04±4.60	108.56±0.68	108.40±1.02	108.24±1.52

Note: Data were presented as the mean ±SD from 12 rats. Statistical analysis: P < 0.01 compared with control group (untreated controls).