Research Article

Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models

Table 13

Blood biochemical parameters of rats treated with CHB-II-F after 2 weeks of recovery period in the sub-chronic toxicity test.

ParametersDose (g/kg)
Control26.2013.106.55

Male
ALT (U/L)43.75±3.1258.746±7.4048.75±2.3252.00±3.24
AST (U/L)112.25±24.5295.50±5.91105.73±4.50110.50±9.14
ALB (g/L)25.13±1.5429.75±1.5428.93±1.5229.58±0.55
ALP (U/L)159.75±22.01243.25±35.33165.25±18.90183.75±11.52
TP (g/L)64.25±1.2367.10±4.5665.70±0.7663.92±1.50
BUN (mmol/L)6.12±0.517.27±0.247.16±0.237.39±0.65
GLU (mmol/L)7.13±0.539.11±0.318.83±0.859.68±0.95
TG (mmol/L)0.45±0.060.45±0.090.60±0.110.67±0.16
TCHO (mmol/L)1.68±0.022.00±0.061.80±0.051.96±0.10
CK (U/L)499.75±153.54200.25±29.31642.50±255.15427.75±53.23
CRE (μmmol/L)34.50±1.5531.53±5.2537.85±1.3531.03±1.52
CK-MB (U/L)479.75±25.00254.75±35.23562.25±45.02504.00±110.12
T-Bil (μmmol/L)0.78±0.190.55±0.190.93±0.220.95±0.14
GGT (U/L)2.50±1.040.50±0.252.00±0.710.50±0.26
K (mmol/L)5.61±0.359.15±0.556.54±0.506.45±0.53
Na (mmol/L)137.20±4.45136.65±1.14137.63±1.56139.96±1.54
Cl (mmol/L)101.08±4.33106.10±1.36102.70±0.44103.75±1.52
Female
ALT (U/L)39.00±3.3748.00±5.4248.50±1.5240.00±6.45
AST (U/L)94.00±5.2588.50±8.60110.25±12.3693.50±9.52
ALB (g/L)31.40±1.5231.60±1.3231.35±0.5229.30±1.68
ALP (U/L)79.75±5.03102.00±14.3093.00±3.6288.00±13.20
TP (g/L)70.02±3.6266.62±2.2669.30±1.5364.61±3.41
BUN (mmol/L)8.33±0.638.80±0.738.19±1.267.84±0.32
GLU (mmol/L)6.58±0.367.07±0.237.36±1.026.69±0.62
TG (mmol/L)0.30±0.040.27±0.020.40±0.070.45±0.13
TCHO (mmol/L)1.75±0.211.78±0.112.04±0.072.02±0.09
CK (U/L)401.25±94.21176.50±16.23379.75±81.04326.25±61.24
CRE (μmmol/L)41.67±2.2540.35±2.0237.85±1.3637.38±1.12
CK-MB (U/L)428.00±55.36192.50±18.04508.75±112.23491.50±105.41
T-Bil (μmmol/L)0.77±0.130.45±0.450.72±0.080.87±0.15
GGT (U/L)1.50±0.250.75±0.451.50±0.521.25±0.45
K (mmol/L)5.39±0.346.39±0.355.86±0.355.47±0.51
Na (mmol/L)133.15±4.52134.05±5.42140.85±0.95129.38±3.51
Cl (mmol/L)99.15±3.50104.50±4.35104.49±0.1698.58±2.53

Note: Data were presented as the mean ±SD from 6 rats. No statistically significant differences were found (P > 0.05).