Research Article
Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models
Table 13
Blood biochemical parameters of rats treated with CHB-II-F after 2 weeks of recovery period in the sub-chronic toxicity test.
| Parameters | Dose (g/kg) | Control | 26.20 | 13.10 | 6.55 |
| Male | | ALT (U/L) | 43.75±3.12 | 58.746±7.40 | 48.75±2.32 | 52.00±3.24 | AST (U/L) | 112.25±24.52 | 95.50±5.91 | 105.73±4.50 | 110.50±9.14 | ALB (g/L) | 25.13±1.54 | 29.75±1.54 | 28.93±1.52 | 29.58±0.55 | ALP (U/L) | 159.75±22.01 | 243.25±35.33 | 165.25±18.90 | 183.75±11.52 | TP (g/L) | 64.25±1.23 | 67.10±4.56 | 65.70±0.76 | 63.92±1.50 | BUN (mmol/L) | 6.12±0.51 | 7.27±0.24 | 7.16±0.23 | 7.39±0.65 | GLU (mmol/L) | 7.13±0.53 | 9.11±0.31 | 8.83±0.85 | 9.68±0.95 | TG (mmol/L) | 0.45±0.06 | 0.45±0.09 | 0.60±0.11 | 0.67±0.16 | TCHO (mmol/L) | 1.68±0.02 | 2.00±0.06 | 1.80±0.05 | 1.96±0.10 | CK (U/L) | 499.75±153.54 | 200.25±29.31 | 642.50±255.15 | 427.75±53.23 | CRE (μmmol/L) | 34.50±1.55 | 31.53±5.25 | 37.85±1.35 | 31.03±1.52 | CK-MB (U/L) | 479.75±25.00 | 254.75±35.23 | 562.25±45.02 | 504.00±110.12 | T-Bil (μmmol/L) | 0.78±0.19 | 0.55±0.19 | 0.93±0.22 | 0.95±0.14 | GGT (U/L) | 2.50±1.04 | 0.50±0.25 | 2.00±0.71 | 0.50±0.26 | K (mmol/L) | 5.61±0.35 | 9.15±0.55 | 6.54±0.50 | 6.45±0.53 | Na (mmol/L) | 137.20±4.45 | 136.65±1.14 | 137.63±1.56 | 139.96±1.54 | Cl (mmol/L) | 101.08±4.33 | 106.10±1.36 | 102.70±0.44 | 103.75±1.52 | Female | | ALT (U/L) | 39.00±3.37 | 48.00±5.42 | 48.50±1.52 | 40.00±6.45 | AST (U/L) | 94.00±5.25 | 88.50±8.60 | 110.25±12.36 | 93.50±9.52 | ALB (g/L) | 31.40±1.52 | 31.60±1.32 | 31.35±0.52 | 29.30±1.68 | ALP (U/L) | 79.75±5.03 | 102.00±14.30 | 93.00±3.62 | 88.00±13.20 | TP (g/L) | 70.02±3.62 | 66.62±2.26 | 69.30±1.53 | 64.61±3.41 | BUN (mmol/L) | 8.33±0.63 | 8.80±0.73 | 8.19±1.26 | 7.84±0.32 | GLU (mmol/L) | 6.58±0.36 | 7.07±0.23 | 7.36±1.02 | 6.69±0.62 | TG (mmol/L) | 0.30±0.04 | 0.27±0.02 | 0.40±0.07 | 0.45±0.13 | TCHO (mmol/L) | 1.75±0.21 | 1.78±0.11 | 2.04±0.07 | 2.02±0.09 | CK (U/L) | 401.25±94.21 | 176.50±16.23 | 379.75±81.04 | 326.25±61.24 | CRE (μmmol/L) | 41.67±2.25 | 40.35±2.02 | 37.85±1.36 | 37.38±1.12 | CK-MB (U/L) | 428.00±55.36 | 192.50±18.04 | 508.75±112.23 | 491.50±105.41 | T-Bil (μmmol/L) | 0.77±0.13 | 0.45±0.45 | 0.72±0.08 | 0.87±0.15 | GGT (U/L) | 1.50±0.25 | 0.75±0.45 | 1.50±0.52 | 1.25±0.45 | K (mmol/L) | 5.39±0.34 | 6.39±0.35 | 5.86±0.35 | 5.47±0.51 | Na (mmol/L) | 133.15±4.52 | 134.05±5.42 | 140.85±0.95 | 129.38±3.51 | Cl (mmol/L) | 99.15±3.50 | 104.50±4.35 | 104.49±0.16 | 98.58±2.53 |
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Note: Data were presented as the mean ±SD from 6 rats. No statistically significant differences were found (P > 0.05).
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